Levetiracetam reduces myoclonus in corticobasal degeneration: report of two cases
Tóm tắt
Levetiracetam (LEV) has been shown to suppress myoclonus of various origins. Corticobasal degeneration (CBD), a progressive neurodegenerative disorder with Parkinsonian syndrome, is frequently accompanied by myoclonus. We investigated the effect of LEV on myoclonus in two CBD patients. LEV remarkably decreased the myoclonic activity in both patients already at 1,500 mg/day dose. This is the first report on LEV alleviating myoclonus in CBD. Our data indicate that it might be worthwhile to assess this effect in an appropriately designed study.
Tài liệu tham khảo
Agarwal P, Frucht SJ (2003) Myoclonus. Curr Opin Neurol 16:515–521
Beran RG, Berkovic SF, Black AB et al (2005) Efficacy of levetiracetam 1000–3000 mg/day in patients with refractory partial-onset seizures: a multicenter, open label single-arm study. Epilepsy Res 63:1–9
Berkovic SF, Knowlton RC, Leroy RF, Schiemann J, Falter U, The Levetiracetam N01057 Study Group (2007) Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 69:1751–1760
Boeve BF, Lamg AE, Litvan I (2003) Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol 54:S15–S19
Crest C, Dupont S, Leguern E et al (2004) Levetiracetam in progressive myoclonic epilepsy. An exploratory study in 9 patients. Neurology 62:640–643
D’Amelio M, Callari G, Gammino M et al (2005) Levetiracetam in the treatment of vascular chorea: a case report. Eur J Clin Pharmacol 60:835–836
de Tommaso M, di Fruscolo O, Sciruicchio V et al (2005) Efficacy of levetiracetam in Huntington disease. Clin Neuropharmacol 28:280–284
Fahn S (2002) Overview, history, and classification of myoclonus. Adv Neurol 89:13–17
Frucht S, Leurgans S, Hallet M et al (2000) The Unified Myoclonus Rating Scale (UMRS): a statistically validated clinical rating instrument for evaluating patients with myoclonus. Mov Disord 15(Suppl 3):107
Grisoli M, Fetoni V, Savoiardo M et al (1995) MRI in corticobasal degeneration. Eur J Neurol 2:547–552
Grosse P, Kühn A, Cordivari C, Brown P (2003) Coherence analysis in the myoclonus of corticobasal degeneration. Mov Disord 18:1345–1350
Keswani SC, Kossoff EH, Krauss GL et al (2002) Amelioration of spinal myoclonus with levetiracetam. J Neurol Neurosurg Psychiatry 73:457–458
Kompoliti K, Goetz CG, Boeve BF et al (1998) Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 55:957–961
Krauss GL, Bergin MB, Kramer RE et al (2001) Suppression of post-hypoxic and post-encephalitic myoclonus with levetiracetam. Neurology 56:411–412
Litvan I, Bhatia KP, Burn DJ et al (2003) SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord 18:467–486
Lynch BA, Lambeng N, Nocka K et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracteam. Proc Natl Acad Sci USA 101:9861–9866
Lyons KE, Pahwa R (2006) Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia. Clin Neuropharmacol 29:148–153
Margineanu DG, Klitgaard H (2000) Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. Pharmacol Res 42:281–285
Meco G, Fabrizio E, Epifanio A et al (2006) Levetiracetam in tardive dyskinesia. Clin Neuropharmacol 29:265–268
Mima T, Nagamini T, Ikeda A et al (1998) Pathogenesis of cortical myoclonus studied by magnetoencephalography. Ann Neurol 43:598–607
Riley DE, Lang AE, Lewis A et al (1990) Cortical-basal ganglionic degeneration. Neurology 40:1203–1212
Sawle GV, Brooks DJ, Marsden CD et al (1991) Corticobasal degeneration: a unique pattern of regional cortical oxygen metabolism and striatal fluorodopa uptake demonstrated by positron emission tomography. Brain 114:541–556
Shibasaki H, Kuroiwa Y (1975) Electroencephalographic correlates of myoclonus. Electroencephalogr Clin Neurophysiol 36:455–463
Storey E, Lichtenstein M, Desmond P et al (1995) Clinical features and SPECT scanning in presumed corticobasal ganglionic degeneration. J Clin Neurosci 2:321–328
Striano P, Manganelli F, Boccella P et al (2005) Levetiracetam in patients with cortical myoclonus: a clinical and electrophysiological study. Mov Disord 20:1610–1614
Thompson PD, Day BL, Rothwell JC et al (1994) The myoclonus in corticobasal degeneration. Brain 117:1197–1207
Wadia PM, Lang AE (2007) The many faces of corticobasal degeneration. Parkinsonism Relat Disord 13:S336–S340
Zesiewicz TA, Louis ED, Sulivan KL et al (2004) Substantial improvement in a Meige’s syndrome patient with levetiracteam treatment. Mov Disord 19:1518–1521