Levetiracetam reduces myoclonus in corticobasal degeneration: report of two cases

Journal of Neural Transmission - Tập 116 - Trang 1631-1634 - 2009
Tibor Kovács1, Marianna Farsang1, Edina Vitaszil1, Péter Barsi2, Tamás Györke3, Imre Szirmai1, Anita Kamondi1
1Department of Neurology, Semmelweis University, Budapest, Hungary
2MRI Research Centre, János Szentágothai Knowledge Centre, Semmelweis University, Budapest, Hungary
3Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

Tóm tắt

Levetiracetam (LEV) has been shown to suppress myoclonus of various origins. Corticobasal degeneration (CBD), a progressive neurodegenerative disorder with Parkinsonian syndrome, is frequently accompanied by myoclonus. We investigated the effect of LEV on myoclonus in two CBD patients. LEV remarkably decreased the myoclonic activity in both patients already at 1,500 mg/day dose. This is the first report on LEV alleviating myoclonus in CBD. Our data indicate that it might be worthwhile to assess this effect in an appropriately designed study.

Tài liệu tham khảo

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