LOCAL KALLIKREIN AND TRYPSIN RESPONSES IN THE RAT

British Journal of Pharmacology - Tập 69 Số 4 - Trang 625-629 - 1980
Amanda J. Bennett1, G.B. West1
1Department of Paramedical Sciences, North East London Polytechnic, Romford Road, London E15 4LZ

Tóm tắt

Locally administered commercial hog pancreatic kallikrein (Depot‐Glumorin) and bovine pancreatic tyrpsin both increased vascular permeability in the skin and paws of rats. By the use of numerous antagonists and enzyme inhibitors, this vascular response was found to be the result not of kinin formation but of a direct action mostly on histamine receptors. Highly purified kallikrein did not increase vascular permeability in rats, suggesting either that the effect was due to an impurity in the commercial preparation or that a structural change in the enzyme occurred on purification. Soya bean trypsin inhibitor prevented the trypsin response when both were injected locally. On intraperitoneal injection, the inhibitor was effective only against local kallikrein. The kallikrein inhibitor, aprotinin (Trasylol), was not effective against local kallikrein but it reduced the trypsin response when both were injected locally.

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Tài liệu tham khảo

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Thông tin xuất bản

British Journal of Pharmacology

Tập 69 Số 4

625-629

Thông tin tác giả