LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants

Bioinformatics - Tập 31 Số 21 - Trang 3555-3557 - 2015
Mitchell J. Machiela1, Stephen J. Chanock1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA

Tóm tắt

Abstract Summary: Assessing linkage disequilibrium (LD) across ancestral populations is a powerful approach for investigating population-specific genetic structure as well as functionally mapping regions of disease susceptibility. Here, we present LDlink, a web-based collection of bioinformatic modules that query single nucleotide polymorphisms (SNPs) in population groups of interest to generate haplotype tables and interactive plots. Modules are designed with an emphasis on ease of use, query flexibility, and interactive visualization of results. Phase 3 haplotype data from the 1000 Genomes Project are referenced for calculating pairwise metrics of LD, searching for proxies in high LD, and enumerating all observed haplotypes. LDlink is tailored for investigators interested in mapping common and uncommon disease susceptibility loci by focusing on output linking correlated alleles and highlighting putative functional variants. Availability and implementation: LDlink is a free and publically available web tool which can be accessed at http://analysistools.nci.nih.gov/LDlink/. Contact: [email protected]

Từ khóa


Tài liệu tham khảo

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Thông tin xuất bản

Bioinformatics

Tập 31 Số 21

3555-3557

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