Kinetics of Anti‐Mannan Antibodies Useful in Confirming Invasive Candidiasis in Immunocompromised Patients

Microbiology and Immunology - Tập 40 Số 2 - Trang 125-131 - 1996
A. Johanna M. van Deventer1, Wil H. F. Goessens1, J H van Zeijl2, Jan W. Mouton1, M. F. Michel1, Henri A. Verbrugh1
1Department of Clinical Microbiology and Antimicrobial Therapy Erasmus University School of Medicine Rotterdam The Netherlands
2Department of Bacteriology St. Laurentius Hospital P. O. Box 920, 6040 AX Roermond The Netherlands

Tóm tắt

AbstractIn studying the anti‐mannan antibodies longitudinally in serial serum samples of three immunocompromised patients, it was observed that anti‐mannan antibodies started to increase shortly after the moment that cultures of deep‐tissue sites became positive with Candida albicans. The mean anti‐mannan antibody titers determined in a group of 36 immunocompromised patients with invasive candidiasis increased within two weeks after the probable onset of invasive candidiasis. In contrast, anti‐mannan antibody levels in serial serum samples of 14 immunocompromised patients who were only colonized with C. albicans remained stable or decreased over time. The HA test measuring the anti‐mannan antibodies was 64% sensitive and 89% specific in determining invasive candidiasis. In contrast, antibodies specific for candidal cytoplasmic antigens or enolase alone were of little value in confirming invasive candidiasis in these immunocompromised patients.

Từ khóa


Tài liệu tham khảo

10.1016/S0344-0338(11)80477-2

10.1016/0732-8893(93)90020-8

10.1136/jcp.31.12.1161

Ellsworth J.H., 1977, Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A, J. Clin. Microbiol., 5, 91, 10.1128/jcm.5.1.91-99.1977

10.1016/0022-1759(92)90319-O

10.1093/infdis/148.2.275

10.1016/0022-1759(79)90287-4

Jones J.M., 1980, Kinetics of antibody responses to cell wall mannan and a major cytoplasmic antigen of Candida albicans in rabbits and humans, J. Lab. Clin. Med., 96, 845

10.1128/CMR.3.1.32

10.1099/00222615-14-4-483

10.1093/clinids/14.Supplement_1.S37

Matthews R.C., 1988, New developments in the serological diagnosis of Candida infection, Mycoses, 31, S34

Mauch H., 1983, Diagnostic value of monitoring kinetics of antibody responses in candidiasis by a solid‐phase radioimmunoassay, Am. J. Clin. Pathol., 79, 200, 10.1093/ajcp/79.2.200

10.1093/infdis/144.1.24

10.1016/0002-9343(81)90162-5

Mohart M., 1994, Evaluation of enzyme immunoassay for Candida cytoplasmic antigens in neutropenic cancer patients, J. Clin. Microbiol., 32, 766, 10.1128/jcm.32.3.766-776.1994

10.1111/j.1651-2227.1995.tb13606.x

10.1007/BF01963834

10.1007/BF01963470

10.1093/clinids/14.Supplement_1.S11

10.1007/BF01709659

Van Deventer A.J.M., 1993, Increased specificity of antibody detection in surgical patients with invasive candidiasis with cytoplasmic antigens depleted of mannan residues, J. Clin. Microbiol., 31, 994, 10.1128/jcm.31.4.994-997.1993

Van Deventer A.J.M., 1994, Diagnostic value of anti‐Candida enolase antibodies, J. Clin. Microbiol., 32, 17, 10.1128/jcm.32.1.17-23.1994

10.1007/BF01964431

Thông tin
Thông tin xuất bản

Microbiology and Immunology

Tập 40 Số 2

125-131

Thông tin tác giả