Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: Similar behavior to sporadic type?

Otolaryngology - Head and Neck Surgery - Tập 142 - Trang 179-183 - 2010
Adriana Figueroa1, Maria Correnti2, Maira Avila3, Aleodor Andea4, Patricia DeVilliers4, Helen Rivera5
1Oral Surgery Residency Program, Central University of Venezuela, Caracas, Venezuela
2Institute of Dental Research, Central University of Venezuela, Caracas, Venezuela
3Molecular Genetics Laboratory of the Oncology and Hematology Institute, Central University of Venezuela, Caracas, Venezuela
4Department of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL
5Oral Pathology Laboratory, Central University of Venezuela, Caracas, Venezuela

Tóm tắt

Objective

The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).

Study Design and Setting

We performed a cross‐sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.

Subjects and Methods

Twelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki‐67 was performed in all 19 cases.

Results

Of the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki‐67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.

Conclusion

On the basis of the analysis of the expression of PCNA, Ki‐67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence.


Tài liệu tham khảo

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Thông tin xuất bản

Otolaryngology - Head and Neck Surgery

Tập 142

179-183

Thông tin tác giả