Ivermectin: A Potent New Antiparasitic Agent

American Association for the Advancement of Science (AAAS) - Tập 221 Số 4613 - Trang 823-828 - 1983
William C. Campbell1, Michael H. Fisher1, E. O. Stapley1, Georg Albers-Schönberg1, Theodore A. Jacob1
1Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065

Tóm tắt

Ivermectin is the 22,23-dihydro derivative of avermectin B 1 , a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis . It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by γ-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.

Từ khóa


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