Isolated corpus callosum agenesis: a ten‐year follow‐up after prenatal diagnosis (How are the children without corpus callosum at 10 years of age?)
Tóm tắt
Corpus callosum agenesis (CCA) is generally diagnosed
We prospectively evaluated 17 children. Clinical examinations, neuropsychological tests were performed each year. School achievement and personal and familial data were collected.
Twelve children completed the entire follow up. One child was finally considered to have associated CCA, because signs of fetal alcohol syndrome had become obvious. Of the 11 other children, three (27%) had borderline intelligence whereas the intelligence levels of eight (73%) were in the normal range, although half of these children experienced some difficulties in scholastic achievement. Neither epilepsy nor intellectual deficiency was noted and intellectual quotient scores correlated strongly with the mother's education level.
Although prenatal diagnosis of isolated CCA is reliable, false postnatal diagnoses remain possible (10–20%) even with complete prenatal screening. Outcome is mostly favorable because intelligence is within the normal range for nearly 3/4 of the children. However, they frequently have mild learning difficulties. © 2012 John Wiley & Sons, Ltd.
Từ khóa
Tài liệu tham khảo
Wechsler D, 1991, Manual for the Wechsler intelligence scale for children
Rey A, 2006, A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary, 326
Tiffin J, 1961, Examiner manual for the Purdue pegboard
Rey A, 1941, L'examen psychologique dans le cas d'encéphalopathie traumatique, Archiv Psychol, 28, 286
Rapp B, 2002, Value of fetal cerebral magnetic resonance imaging for the prenatal diagnosis and prognosis of corpus callosum agenesis, J Gynecol Obstet Biol Reprod, 31, 173
Chadie A, 2008, Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum, ActaPaediatr, 97, 420
Ramelli G, 2006, The prognosis of agenesis of the corpus callosum might mostly be favourable, Swiss Med Wkly, 136, 404
Nieto‐Barrera M, 1999, Corpus callosum agenesis and epileptic seizures, Rev Neurol, 28, S6
Pisani F, 2000, Clinical features in subjects with congenital anomalies of the corpus callosum, Acta Bioned Ateneo Parmense, 71, 497