Tính không thể đảo ngược của sự già hóa tế bào: vai trò kép của con đường p16INK4a/Rb trong kiểm soát chu kỳ tế bào
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ben-Porath I, Weinberg RA: When cells get stressed: an integrative view of cellular senescence. J Clin Invest 2004,113(1):8–13. 10.1172/JCI200420663
Campisi J: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005,120(4):513–522. 10.1016/j.cell.2005.02.003
Herbig U, Sedivy JM: Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev 2006,127(1):16–24. 10.1016/j.mad.2005.09.002
Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M: Tumour biology: senescence in premalignant tumours. Nature 2005,436(7051):642. 10.1038/436642a
Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, Stein H, Dorken B, Jenuwein T, Schmitt CA: Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005,436(7051):660–665. 10.1038/nature03841
Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS: BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005,436(7051):720–724. 10.1038/nature03890
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP: Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005,436(7051):725–730. 10.1038/nature03918
Sharpless NE, DePinho RA: Cancer: crime and punishment. Nature 2005,436(7051):636–637. 10.1038/436636a
Campisi J: Suppressing cancer: the importance of being senescent. Science 2005,309(5736):886–887. 10.1126/science.1116801
Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T: Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 2003,424(6945):223–228. 10.1038/nature01764
Dirac AM, Bernards R: Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 2003,278(14):11731–11734. 10.1074/jbc.C300023200
Dai CY, Enders GH: p16 INK4a can initiate an autonomous senescence program. Oncogene 2000,19(13):1613–1622. 10.1038/sj.onc.1203438
Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J: Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003,22(16):4212–4222. 10.1093/emboj/cdg417
Ramsey MR, Sharpless NE: ROS as a tumour suppressor? Nat Cell Biol 2006,8(11):1213–1215. 10.1038/ncb1106-1213
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E: Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006,8(11):1291–1297. 10.1038/ncb1491
Sherr CJ, McCormick F: The RB and p53 pathways in cancer. Cancer Cell 2002,2(2):103–112. 10.1016/S1535-6108(02)00102-2
Cobrinik D: Pocket proteins and cell cycle control. Oncogene 2005,24(17):2796–2809. 10.1038/sj.onc.1208619
Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S, Oda T, Sugimura H, Kamijo T, Ookawa K, Yasuda H, Kitagawa M: Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J 2005,24(1):160–169. 10.1038/sj.emboj.7600486
Chan HM, Krstic-Demonacos M, Smith L, Demonacos C, La Thangue NB: Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol 2001,3(7):667–674. 10.1038/35083062
Gonzalo S, Garcia-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE, Eguia R, Dean DC, Esteller M, Jenuwein T, Blasco MA: Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol 2005,7(4):420–428. 10.1038/ncb1235
Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999,13(12):1501–1512.
Ciemerych MA, Sicinski P: Cell cycle in mouse development. Oncogene 2005,24(17):2877–2898. 10.1038/sj.onc.1208608
Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P: Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006,10(5):563–573. 10.1016/j.devcel.2006.03.004
Malumbres M, Barbacid M: Cell cycle kinases in cancer. Curr Opin Genet Dev 2007,17(1):60–65. 10.1016/j.gde.2006.12.008
Dimova DK, Dyson NJ: The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005,24(17):2810–2826. 10.1038/sj.onc.1208612
Trimarchi JM, Lees JA: Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002,3(1):11–20. 10.1038/nrm714
Rowland BD, Bernards R: Re-evaluating cell-cycle regulation by E2Fs. Cell 2006,127(5):871–874. 10.1016/j.cell.2006.11.019
Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994,211(1):90–98. 10.1006/excr.1994.1063
Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996,16(3):859–867.
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997,88(5):593–602. 10.1016/S0092-8674(00)81902-9
Gil J, Peters G: Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006,7(9):667–677. 10.1038/nrm1987
El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell 1993,75(4):817–825. 10.1016/0092-8674(93)90500-P
Gu Y, Turck CW, Morgan DO: Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 1993,366(6456):707–710. 10.1038/366707a0
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993,75(4):805–816. 10.1016/0092-8674(93)90499-G
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 1993,366(6456):701–704. 10.1038/366701a0
El-Deiry WS: p21/p53, cellular growth control and genomic integrity. Curr Top Microbiol Immunol 1998, 227: 121–137.
Deng C, Zhang P, Harper JW, Elledge SJ, Leder P: Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995,82(4):675–684. 10.1016/0092-8674(95)90039-X
Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ: Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 1995,377(6549):552–557. 10.1038/377552a0
Pantoja C, Serrano M: Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 1999,18(35):4974–4982. 10.1038/sj.onc.1202880
Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993,366(6456):704–707. 10.1038/366704a0
McConnell BB, Gregory FJ, Stott FJ, Hara E, Peters G: Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 1999,19(3):1981–1989.
Mitra J, Dai CY, Somasundaram K, El-Deiry WS, Satyamoorthy K, Herlyn M, Enders GH: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). Mol Cell Biol 1999,19(5):3916–3928.
Quelle DE, Zindy F, Ashmun RA, Sherr CJ: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995,83(6):993–1000. 10.1016/0092-8674(95)90214-7
Sherr CJ: Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 2006,6(9):663–673. 10.1038/nrc1954
Tsuyama N, Miura M, Kitahira M, Ishibashi S, Ide T: SV40 T-antigen is required for maintenance of immortal growth in SV40-transformed human fibroblasts. Cell Struct Funct 1991,16(1):55–62.
Tahara H, Sato E, Noda A, Ide T: Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 1995,10(5):835–840.
Finkel T: Oxidant signals and oxidative stress. Curr Opin Cell Biol 2003,15(2):247–254. 10.1016/S0955-0674(03)00002-4
Konishi H, Tanaka M, Takemura Y, Matsuzaki H, Ono Y, Kikkawa U, Nishizuka Y: Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci USA 1997,94(21):11233–11237. 10.1073/pnas.94.21.11233
Wheaton K, Riabowol K: Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol Cell Biol 2004,24(16):7298–7311. 10.1128/MCB.24.16.7298-7311.2004
Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene 2004,23(31):5266–5274. 10.1038/sj.onc.1207623
Yang X, Yu K, Hao Y, Li DM, Stewart R, Insogna KL, Xu T: LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol 2004,6(7):609–617. 10.1038/ncb1140
Bothos J, Tuttle RL, Ottey M, Luca FC, Halazonetis TD: Human LATS1 is a mitotic exit network kinase. Cancer Res 2005,65(15):6568–6575. 10.1158/0008-5472.CAN-05-0862
Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003,113(6):703–716. 10.1016/S0092-8674(03)00401-X
Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 2005,8(1):19–30. 10.1016/j.devcel.2004.10.019
Narita M, Narita M, Krizhanovsky V, Nunez S, Chicas A, Hearn SA, Myers MP, Lowe SW: A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 2006,126(3):503–514. 10.1016/j.cell.2006.05.052
Funayama R, Saito M, Tanobe H, Ishikawa F: Loss of linker histone H1 in cellular senescence. J Cell Biol 2006,175(6):869–880. 10.1083/jcb.200604005
Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB: p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 2000,19(17):2165–2170. 10.1038/sj.onc.1203573
Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K: A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006,10(6):459–472. 10.1016/j.ccr.2006.10.003
Shay JW, Roninson IB: Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004,23(16):2919–2933. 10.1038/sj.onc.1207518
Dimri GP: What has senescence got to do with cancer? Cancer Cell 2005,7(6):505–512. 10.1016/j.ccr.2005.05.025
Schmitt CA: Cellular senescence and cancer treatment. Biochim Biophys Acta 2007,1775(1):5–20.