Iron and malaria: a dangerous liaison?

World Health Organization. World Malaria Report 2015. Geneva, Switzerland: World Health Organization; 2015.

de Benoist B McLean E Egli I CM ., eds. Worldwide Prevalence of Anaemia 1993–2005: WHO Global Database on Anaemia. Geneva, Switzerland: WHO Press; 2005.

World Health Organization. Iron deficiency anaemia: assesment, prevention, and control. A guide for programme managers. Geneva, Switerland: World Health Organization; 2001.

10.1016/j.jpeds.2013.05.015

Stoltzfus RJ Dreyfuss ML , eds. Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. Washington. DC: ILSI Press; 1998.

Kochan I. The role of iron in bacterial infections, with special consideration of host-tubercle bacillus interaction. In: Arber W Braun W Haas R ., eds. Current Topics in Microbiology and Immunology. Vol 60. Berlin: Springer-Verlag; 1973:1–30.

10.1016/S0140-6736(75)91758-4

10.1136/bmj.2.6145.1113

10.1016/0035-9203(86)90154-9

10.1086/422331

Sazawal S Black RE Ramsan M Chwaya HM Stoltzfus RJ Dutta A Deb S . (2006). Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet, 367:133–143.

World Health Organization. Iron Supplementation of Young Children in Regions Where Malaria Transmission is Intense and Infectious Disease Highly Prevalent. Geneva, Switzerland: World Health Organization; 2006.

World Health Organization. World Malaria Report 2014. Geneva, Switzerland; 2014.

World Health Organization. Report on the Malaria Conference in Equatorial Africa. Held under the Joint Auspices of the World Health Organization and of the Commission for Technical Co-operation in Africa South of the Sahara, 27 November–9 December, 1950 Kampala, Uganda. Geneva, Switzerland: World Health Organization; 1951. Technical Report Series No. 38.

10.1086/422331

Gwamaka, 2012, Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children, Clin Infect Dis, 20852, 1137, 10.1093/cid/cis010

10.1016/S0140-6736(97)04229-3

World Health Organisation. WHO Policy Recommendation on Intermittent Preventive Treatment during Infancy for Plasmodium falciparum Malaria Control in Africa. Geneva, Switzerland: World Health Organization; 2010.

10.1371/journal.pmed.1001125

10.1001/jama.2013.277129

Ojukwu JU Okebe JU Yahav D Paul M . (2010). Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas: Cochrane systematic review. Int J Epidemiol. 39(4), 32–35. http://doi.org/10.1093/ije/dyp368 .

Okebe, 2011, Oral iron supplements for children in malaria-endemic areas, Cochrane Database Syst Rev, 10, CD006589

Neuberger A Yahav D . (2016). Oral iron supplements for children in malaria-endemic areas. Cochrane Database of Systematic Reviews. (2), 202. http://doi.org/10.1002/14651858.CD006589.pub3 .

10.1136/jclinpath-2013-202122

10.1016/j.diagmicrobio.2015.10.002

Tielsch JM Khatry SK Stoltzfus RJ Katz J Leclerq SC Adhikari R Mullany LC . (2006). Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern controlled trial, 367.

10.1371/journal.pone.0087743

Slavic, 2016, A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium, Nat Commun, 7, 1, 10.1038/ncomms10403

10.1038/ncomms5446

Fairweather-Tait, 1989, Studies of iron:zinc interactions in adult rats and the effect of iron fortification of two commercial infant weaning products on iron and zinc status of weanling rats, J Nutr, 119, 599, 10.1093/jn/119.4.599

10.1016/S0962-8924(00)01900-0

10.1016/j.ab.2005.03.008

10.1017/S0031182000084729

Turner, 1998, Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity, Am J Pathol, 152, 1477

10.1096/fj.05-4700fje

10.1024/0300-9831/a000035

Scholl PF Tripathi AK Sullivan DJ. Bioavailable iron and heme metabolism in Plasmodium falciparum . In: Sullivan DJ Krishna S , eds. Malaria: Drugs, Disease and Post-Genomic Biology. Berlin, Germany: Springer; 2005:293–324.

10.1371/journal.pmed.0020340

10.1086/432519

Onyenekwe CC Ukibe N Meludu SC . Possible biochemical impact of malaria infection in subjects with HIV co-infection in Anambra state, Nigeria. J Vector Borne Dis. 2008;151–156.

10.1097/00006454-200004000-00010

10.1128/IAI.73.6.3531-3539.2005

Joint World Health Organization/Centers for Disease Control and Technical Consultation on the Assessment of Iron Status at the Population Level. Assessing the Iron Status of Populations. 2nd ed. Geneva, Switzerland: World Health Organization; 2004.

Mei, 2005, Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials, J Nutr, 135, 1974, 10.1093/jn/135.8.1974

10.1177/15648265070284S413

10.1371/journal.pone.0002133

10.3945/ajcn.115.117820

10.1681/ASN.2006070802

Howard, 2007, Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana, Am J Trop Med Hyg, 77, 623, 10.4269/ajtmh.2007.77.623

10.3324/haematol.2012.065854

10.1182/blood-2012-10-461418

10.1001/jama.1987.03400030055031

10.1016/0046-8177(93)90300-6

10.1097/01.mpg.0000243440.85452.38

Moya-Alvarez V Cottrell G Ouédraogo S . Does iron increase the risk of malaria in pregnancy?. Open Forum Infect Dis. 2015;2:ofv038.