Iron Promotes Intestinal Development in Neonatal Piglets

Nutrients - Tập 10 Số 6 - Trang 726
Yutian Pu1, Shuhui Li1, Haitao Xiong2,1, Qian Zhang3, Yizhen Wang1, Huahua Du1
1Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou 310058, China
2College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
3Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Tóm tắt

Early nutrition is key to promoting gut growth and education of the immune system. Although iron deficiency anemia has long been recognized as a serious iron disorder, the effects of iron supplementation on gut development are less clear. Therefore, using suckling piglets as the model for iron deficiency, we assessed the impacts of iron supplementation on hematological status, gut development, and immunity improvement. Piglets were parenterally supplied with iron dextran (FeDex, 60 mg Fe/kg) by intramuscular administration on the third day after birth and slaughtered at the age of two days, five days, 10 days, and 20 days. It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN). FeDex supplementation increased villus length and crypt depth, attenuated the pathological status of the duodenum, and was beneficial to intestinal mucosa. FeDex also influenced the intestinal immune development by stimulating the cytokines’ production of the intestine and enhancing the phagocytotic capacity of monocytes. Overall, the present study suggested that iron supplementation helped promote the development of the intestine by improving its morphology, which maintains its mucosal integrity and enhances the expression of immuno-associated factors.

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Tài liệu tham khảo

McLean, 2009, Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005, Public Health Nutr., 12, 444, 10.1017/S1368980008002401

Clark, 2009, Iron deficiency anemia: Diagnosis and management, Curr. Opin. Gastroenterol., 25, 122, 10.1097/MOG.0b013e32831ef1cd

Lipinski, 2010, Benefits and risks of iron supplementation in anemic neonatal pigs, Am. J. Pathol., 177, 1233, 10.2353/ajpath.2010.091020

Gozzelino, R., and Arosio, P. (2016). Iron homeostasis in health and disease. Int. J. Mol. Sci., 17.

Rao, 2007, Iron in fetal and neonatal nutrition, Semin. Fetal Neonatal Med., 12, 54, 10.1016/j.siny.2006.10.007

Beard, 2001, Iron biology in immune function, muscle metabolism and neuronal functioning, J. Nutr., 131, 568S, 10.1093/jn/131.2.568S

Kramer, 2002, Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (WAF1/CIP1) and requires iron, Br. J. Haematol., 117, 727, 10.1046/j.1365-2141.2002.03498.x

Cassat, 2013, Iron in infection and immunity, Cell Host Microbe, 13, 509, 10.1016/j.chom.2013.04.010

Hallquist, 1992, Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups, Am. J. Clin. Nutr., 55, 741, 10.1093/ajcn/55.3.741

Bonaccorsi-Riani, E., Danger, R., Lozano, J.J., Martinez-Picola, M., Kodela, E., Mas-Malavila, R., Bruguera, M., Collins, H.L., Hider, R.C., and Martinez-Llordella, M. (2015). Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response. PLoS ONE, 10.

2008, Bioavailability of heme iron in biscuit filling using piglets as an animal model for humans, Int. J. Biol. Sci., 4, 58

Svoboda, 2005, Iron deficiency in suckling piglets: Etiology, clinical aspects and diagnosis, Folia Vet., 49, 104

Egeli, 1999, An evaluation of iron-dextran supplementation in piglets administered by injection on the first, third or fourth day after birth, Res. Vet. Sci., 66, 179, 10.1053/rvsc.1998.0223

Asanuma, 2010, Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease, Gut, 59, 258, 10.1136/gut.2009.176651

Lin, 2007, Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4, Blood, 110, 2182, 10.1182/blood-2007-04-087593

Nemeth, 2004, Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization, Science, 306, 2090, 10.1126/science.1104742

Nguyen, 2007, Transfer of maternal cytokines to suckling piglets: In vivo and in vitro models with implications for immunomodulation of neonatal immunity, Vet. Immunol. Immunopathol., 117, 236, 10.1016/j.vetimm.2007.02.013

Gordon, 2016, Phagocytosis: An Immunobiologic Process, Immunity, 44, 463, 10.1016/j.immuni.2016.02.026

2010, Iron homeostasis and the inflammatory response, Annu. Rev. Nutr., 30, 105, 10.1146/annurev.nutr.012809.104804

Meurens, 2012, The pig: A model for human infectious diseases, Trends Microbiol., 20, 50, 10.1016/j.tim.2011.11.002

Comstock, 2014, Dietary bovine lactoferrin alters mucosal and systemic immune cell responses in neonatal piglets, J. Nutr., 144, 525, 10.3945/jn.113.190264

Hansen, 2009, Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs, J. Nutr., 139, 1474, 10.3945/jn.109.105866

Shi, 2008, A cytosolic iron chaperone that delivers iron to ferritin, Science, 320, 1207, 10.1126/science.1157643

Massupha, 2013, Growth and small intestine histomorphology of low and normal birth weight piglets during the early suckling period, Livest. Sci., 158, 215, 10.1016/j.livsci.2013.10.016

Watson, 2016, Iron depletion suppresses mTORC1-directed signaling in intestinal Caco-2 cells via induction of REDD1, Cell Signal, 28, 412, 10.1016/j.cellsig.2016.01.014

Palmer, 2011, Nutritionally mediated programming of the developing immune system, Adv. Nutr., 2, 377, 10.3945/an.111.000570

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Nutrients

Tập 10 Số 6

726

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