Iron Deficiency Is Associated With Impaired Biventricular Reserve and Reduced Exercise Capacity in Patients With Unexplained Dyspnea

Sarkar, 2006, Evaluation of the dyspneic patient in the office, Prim Care, 33, 643, 10.1016/j.pop.2006.06.007

Shiber, 2006, Dyspnea, Med Clin North Am, 90, 453, 10.1016/j.mcna.2005.11.006

Borlaug, 2020, Evaluation and management of heart failure with preserved ejection fraction, Nat Rev Cardiol, 17, 559, 10.1038/s41569-020-0363-2

Ryan, 2018, The Dyspnea Clinic, Circulation, 137, 1994, 10.1161/CIRCULATIONAHA.117.029769

Huang, 2017, Invasive cardiopulmonary exercise testing in the evaluation of unexplained dyspnea: Insights from a multidisciplinary dyspnea center, Eur J Prev Cardiol, 24, 1190, 10.1177/2047487317709605

Obokata, 2017, Role of diastolic stress testing in the evaluation for heart failure with preserved ejection fraction: a simultaneous invasive-echocardiographic study, Circulation, 135, 825, 10.1161/CIRCULATIONAHA.116.024822

Borlaug, 2010, Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction, Circ Heart Fail, 3, 588, 10.1161/CIRCHEARTFAILURE.109.930701

Jankowska, 2011, Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure, J Card Fail, 17, 899, 10.1016/j.cardfail.2011.08.003

Martens, 2017, Impact of iron deficiency on exercise capacity and outcome in heart failure with reduced, mid-range and preserved ejection fraction, Acta Cardiol, 73, 115, 10.1080/00015385.2017.1351239

van Veldhuisen, 2017, Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency, Circulation, 136, 1374, 10.1161/CIRCULATIONAHA.117.027497

Hoes, 2018, Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function, Eur J Heart Fail, 20, 910, 10.1002/ejhf.1154

Martens, 2018, Cardiac iron deficiency-how to refuel the engine out of fuel, Eur J Heart Fail, 20, 920, 10.1002/ejhf.1174

Anker, 2018, Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis, Eur J Heart Fail, 20, 125, 10.1002/ejhf.823

Ponikowski, 2015, Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency, Eur Heart J, 36, 657, 10.1093/eurheartj/ehu385

Martens, 2019, Rationale and design of the IRON-CRT trial: effect of intravenous ferric carboxymaltose on reverse remodelling following cardiac resynchronization therapy, ESC Heart Fail, 6, 1208, 10.1002/ehf2.12503

Elliott, 2014, 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), Eur Heart J, 35, 2733, 10.1093/eurheartj/ehu284

Ponikowski, 2016, Eur J Heart Fail, 18, 891, 10.1002/ejhf.592

Pieske, 2019, How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC), Eur Heart J, 40, 3297, 10.1093/eurheartj/ehz641

Ross, 2003, ATS/ACCP statement on cardiopulmonary exercise testing, Am J Respir Crit Care Med, 167, 1451, 10.1164/ajrccm.167.10.950

von, 2007, The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies, Lancet, 370, 1453, 10.1016/S0140-6736(07)61602-X

Guazzi, 2013, Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis, Am J Physiol Heart Circ Physiol, 305, H1373, 10.1152/ajpheart.00157.2013

Yeo, 2014, Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis, Eur J Heart Fail, 16, 1125, 10.1002/ejhf.161

Nunez, 2020, Noninvasive imaging estimation of myocardial iron repletion following administration of intravenous iron: the Myocardial-IRON trial, J Am Heart Assoc, 9, 10.1161/JAHA.119.014254

Anker, 2018, Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis, Eur J Heart Fail, 20, 125, 10.1002/ejhf.823

Martens, 2018, Limited contractile reserve contributes to poor peak exercise capacity in iron-deficient heart failure, Eur J Heart Fail, 20, 806, 10.1002/ejhf.938

Gorter, 2018, Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology, Eur J Heart Fail, 20, 16, 10.1002/ejhf.1029

Melenovsky, 2017, Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis, Eur J Heart Fail, 19, 522, 10.1002/ejhf.640

Charles-Edwards, 2019, Effect of iron isomaltoside on skeletal muscle energetics in patients with chronic heart failure and iron deficiency, Circulation, 139, 2386, 10.1161/CIRCULATIONAHA.118.038516

Houstis, 2018, Exercise intolerance in heart failure with preserved ejection fraction: diagnosing and ranking its causes using personalized O2 pathway analysis, Circulation, 137, 148, 10.1161/CIRCULATIONAHA.117.029058

Reddy, 2018, A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction, Circulation, 138, 861, 10.1161/CIRCULATIONAHA.118.034646