Investigations into the Prevention of Prenatal and Lactogenic Toxocara canis Infections in Puppies by Application of Moxidectin to the Pregnant Dog

Wiley - Tập 53 Số 5 - Trang 218-223 - 2006
Friederike Krämer1, R. Hammerstein2, M. Stoye2, C. Epe3
1Institute for Parasitology, University of Veterinary Medicine Hannover, Foundation, Germany
2Address of the authors: Institute for Parasitology, University of Veterinary Medicine Hannover Foundation, Buenteweg 17, D-30559 Hannover, Germany
3Address of the authors: Institute for Parasitology, University of Veterinary Medicine Hannover Foundation, Buenteweg 17, D‐30559 Hannover, Germany

Tóm tắt

SummaryAim of the investigation was to examine whether two administrations of moxidectin to pregnant dogs could prevent pre‐natal and lactogenic infections of puppies with reactivated Toxocara canis larvae. Four pregnant beagles, infected experimentally with 20 000 embryonated eggs of T. canis, were treated subcutaneously with 1 mg moxidectin per kg body weight on days 40 and 55 of pregnancy (5–13 days before parturition). One further dam and its puppies served as untreated control. Two applications of moxidectin completely prevented pre‐natal and lactogenic infections in the puppies. Neither intestinal stages nor somatic larvae were found in the dams or their corresponding puppies. All puppies and dams of the treatment group remained coproscopically negative until 42 days after parturition. The administration of moxidectin did not show any side effects in the dams. None of the puppies of the treated dams showed any pathological abnormalities. In the untreated dam one adult and 26 somatic larvae of T. canis were detected at necropsy. All puppies of the untreated dam showed a patent T. canis infection from day 28 post‐natum (p.n.); 296 pre‐adult and adult stages of T. canis were spontaneously eliminated and 51 intestinal stages and five somatic larvae of T. canis were recovered at necropsy. In contrast to the puppies of the treated dams all negative control puppies showed blood eosinophilia after parturition and elevated liver enzyme levels.

Từ khóa


Tài liệu tham khảo

Andersen A. C., 1970, The Beagle as an Experimental Dog, 83

Bosse M., 1981, Zur Wirkung verschiedener Benzimidazolcarbamate auf somatische Larven von Ancylostoma caninum ERCOLANI 1859 (Ancylostomidae) und Toxocara canis WERNER 1782 (Anisakidae), Zentralbl. Bakteriol., 28, 265

Bosse M., 1980, Epizootiologie und Bekämpfung neonataler Helmintheninfektionen des Hundes, Fortschr. Vet. Med., 30, 247

10.1016/0020-7519(85)90104-3

10.1046/j.1365-2885.2001.00309.x

10.1007/BF01839009

Düwel D., 1978, Versuche zur Geburt helminthenfreier Hundewelpen durch Fenbendazol‐Behandlung, Dt. Tierärztl. Wschr., 85, 239

Epe C., 1995, A field study on the prevention of prenatal and galactogenic Toxocara canis infections in puppies by treatment of impatently infected bitches with ivermectin or doramectin, Appl. Parasitol., 36, 115

10.1046/j.1439-0450.1999.00232.x

10.2307/3276045

Hammerstein R., 2000, Versuche zur Verhinderung neonataler Infektionen bei Welpen mit Toxocara canis WERNER 1782 (Anisakidae) durch Behandlung der Hündin mit Moxidectin

10.1007/s00436-005-1450-3

Herlich H., 1956, A digestion method for post‐mortem recovery of nematodes from ruminants, Proc. Helm. Soc. Wash., 23, 102

Horn G., 1983, Verhalten und Pathogenität der Larven von Toxocara canis WERNER 1782 (Anisakidae) bei ganzkörperbestrahlten Mäusen

10.1007/s00436-005-1449-9

Leutenegger‐Aste C., 1987, Untersuchung zur Chemotherapie des impatenten und patenten Toxocara canis Befalls des Hundes

Lloyd S., 1993, Toxocara and Toxocariasis: Clinical, Epidemiological and Molecular Perspectives, 11

10.1111/j.1748-5827.1983.tb00365.x

10.2307/3274518

10.1292/jvms1939.30.151

10.1016/0014-4894(66)90055-5

10.3109/10408419709115138

10.1016/S0304-4017(00)00304-6

Petrich J., 1981, Zur Wirkung verschiedener Benzimidazolcarbamate auf somatische Larven von Ancylostoma caninum ERCOLANI 1859 (Ancylostomidae) und Toxocara canis WERNER 1782 (Anisakidae). 3. Immunfluoreszenzserologische Untersuchungen der Titerverläufe behandelter und unbehandelter Hunde, Zentralbl. Bakteriol., 28, 292

Randolph T. G., 1949, Differentiation and enumeration of eosinophils in the counting chamber with a glycol stain, a valuable technique in appraising ACTH dosage, J. Lab. Clin. Med., 34, 1696

Ridley R. K., 1994, Epidemiology and control of helminth parasites in Greyhound breeding farms, Comp. Cont. Educ. Pract. Vet., 16, 585

10.1111/j.1439-0450.1996.tb00285.x

10.1093/infdis/90.2.165

10.1093/infdis/92.2.114

10.1017/S0031182000027414

Stoye M., 1973, Untersuchungen über die Möglichkeit pränataler und galaktogener Infektionen mit Ancylostoma caninum ERCOLANI 1859 (Ancylostomatidae) beim Hund, Zentralbl. Bakteriol., 25, 1

Stoye M., 1976, Galaktogene und pränatale Infektionen mit Toxocara canis beim Hund (Beagle), D. Tierärztl. Wschr., 83, 107

Stoye M., 1989, Toxocara canis, Waltham Rep., 28, 39

Stoye M., 1985, Zur Wirkung von Fenbendazol auf ruhende somatische Larven von Toxocara canis WERNER 1782 (Anisakidae) in der graviden Hündin, Zentralbl. Bakteriol., 37, 81

10.1093/ajcp/24.9.1016

10.1016/0009-8981(61)90145-0

10.1002/bdd.313

10.1016/S0304-4017(00)00357-5

10.1139/z58-038

Wetzel R., 1951, Verbesserte McMaster‐Kammer zum Auszählen von Wurmeiern, Tierärztl. Umsch., 6, 209

10.1016/0304-4017(93)90219-D

Yutuc L. M., 1954, The incidence and prepatent period of Ancylostoma caninum and Toxocara canis in prenatally infected puppies, J. Parasitol., 40, 18

10.1021/jf00038a028