Intrinsic defect of the immune system in children with Down syndrome: a review

Clinical and Experimental Immunology - Tập 156 Số 2 - Trang 189-193 - 2009
Maaike A. Kusters1, Ruud H J Verstegen2, Eugenie Gemen3, Esther de Vries2
1Department of Paediatrics, Jeroen Bosch Hospital (Ioc GZG), Hertogenbosch, the Netherlands.
2Departments of Paediatrics
3Clinical Chemistry and Haematology, Jeroen Bosch Hospital (loc GZG), 's-Hertogenbosch, the Netherlands

Tóm tắt

SummaryDown syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and present results of immunological studies in DS children in relation to the clinical consequences they suffer, we conclude that it is more likely that the DS immune system is intrinsically deficient from the very beginning.

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Tài liệu tham khảo

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