Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

Experimental Hematology & Oncology - Tập 1 - Trang 1-5 - 2012
Sied Kebir1, Klaus Kuchelmeister2, Pitt Niehusmann2, Michael Nelles3, Young Kim4, Sharmilan Thanendrarajan4, Niklas Schäfer1, Moritz Stuplich1, Frederic Mack1, Björn Scheffler5, Horst Urbach3, Martin Glas1,5, Ulrich Herrlinger1
1Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Bonn, Germany
2Department of Neuropathology, University of Bonn Medical Center, Bonn, Bonn, Germany
3Department of Radiology, University of Bonn Medical Center, Bonn, Bonn, Germany
4Department of Oncology, University of Bonn Medical Center, Bonn, Bonn, Germany
5Stem Cell Pathologies, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Bonn, Bonn, Germany

Tóm tắt

Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.

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Experimental Hematology & Oncology

Tập 1

1-5

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