Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review
Tóm tắt
Central nervous system germ cell tumors (CNSGCTs) are rare neoplasms which usually develop in the midline structures. They are occasionally involved in off-midline structures of the brain. Here, we report an extremely rare case of an intracranial germinoma in the lateral ventricle. The patient was a 10-year-old boy with a 1-year history of polydipsia and polyuria. Brain magnetic resonance imaging (MRI) showed a relatively homogeneously enhancing lesion in the lateral ventricle, and the posterior pituitary gland was not hyperintense on T1-weighted imaging. Subependymoma was suspected, and tumor removal operation was performed; however, because the intraoperative pathological investigation revealed germinoma, we could only perform partial removal of the tumor. Postoperative histology also confirmed germinoma. Then, the patient received chemotherapy, followed by radiation therapy. MRI showed no recurrence for 6 years after treatment. Intracranial germinoma in the lateral ventricle is extremely rare. The diagnosis is occasionally challenging, especially when the tumors are located in atypical locations. This paper presents a literature review of previously described CNSGCTs of the lateral ventricle to improve awareness of CNSGCTs in atypical locations. We also consider the relationship between imaging findings and clinical manifestations.
Tài liệu tham khảo
Louis DN, Perry A, Reifenberger G, Von Deimling A, Figarella-Branger D, Cavenee WK et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131(6):803–820. https://doi.org/10.1007/s00401-016-1545-1
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y (2018) Central nervous system germ cell tumors: a review of the literature. J Child Neurol 33(9):610–620. https://doi.org/10.1177/0883073818772470
Jennings MT, Gelman R, Hochberg F (1985) Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 63(2):155–167. https://doi.org/10.3171/jns.1985.63.2.0155
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N et al (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 86(3):446–455. https://doi.org/10.3171/jns.1997.86.3.0446
Tamaki N, Lin T, Shirataki K, Hosoda K, Kurata H, Matsumoto S et al (1990) Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 6(1):3–7. https://doi.org/10.1007/bf00262257
Okamoto K, Ito J, Ishikawa K, Morii K, Yamada M, Takahashi N et al (2002) Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 44(5):389–394. https://doi.org/10.1007/s00234-001-0735-1
Ozelame RV, Shroff M, Wood B, Bouffet E, Bartels U, Drake JM et al (2006) Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 36(4):325–330. https://doi.org/10.1007/s00247-005-0063-4
Wong TT, Chen YW, Guo WY, Chang KP, Ho DM, Yen SH (2008) Germinoma involving the basal ganglia in children. Childs Nerv Syst 24(1):71–78. https://doi.org/10.1007/s00381-007-0495-2
Rasalkar DD, Chu WC, Cheng FW, Paunipagar BK, Shing MK, Li CK (2010) Atypical location of germinoma in basal ganglia in adolescents: radiological features and treatment outcomes. Br J Radiol 83(987):261–267. https://doi.org/10.1259/bjr/25001856
De Vialatte Pemille C, Bielle F, Mokhtari K, Kerboua E, Alapetite C, Idbaih A (2016) Basal ganglia germinoma in an adult. World Neurosurg 92:584.e11-584.e14. https://doi.org/10.1016/j.wneu.2016.05.041
Liu E, Robertson RL, Du Plessis A, Pomeroy SL (1999) Basal ganglia germinoma with progressive cerebral hemiatrophy. Pediatr Neurol 20(4):312–314. https://doi.org/10.1016/s0887-8994(98)00161-1
Akiyama Y, Suzuki H, Mikuni N (2016) Germinoma mimicking tumefactive demyelinating disease in pediatric patients. Pediatr Neurosurg 51(3):149–153. https://doi.org/10.1159/000439028
Khairy S, Khubrani R, Al-Dandan S, Alobaid A (2018) Thalamic germinoma: a challenging diagnosis, case report and literature review. J Surg Case Rep (7):rjy154. https://doi.org/10.1093/jscr/rjy154
Kawasaki K, Yamada M, Hara N, Okamoto K, Tanaka R, Takahashi H (2003) Primary frontal-lobe germinoma appearing as a large cyst. Neuropathology 23(4):307–310. https://doi.org/10.1046/j.1440-1789.2003.00509.x
Ji X, Chao X, Fei Z, Zhao Y (2011) Primary frontoparietal lobe convexity germinoma with dural invasion mimics meningioma. Neurosciences (Riyadh) 16(3):276–280
Luo Z, Qian Z, Yang K, Liu H, Zhang W, Zeng Y (2017) Primary germinoma originating from the insular lobe: a case report and review of the literature. World Neurosurg 98:871.e1-871.e7. https://doi.org/10.1016/j.wneu.2016.12.004
Sato K, Nagayama T, Fujimura M, Okamoto K, Kamiya M, Nakazato Y (2003) A case of germinoma in the septum pellucidum manifesting as amnesia and hemiparesis. Acta Neurochir (Wien) 145(10):923–926. https://doi.org/10.1007/s00701-003-0110-6
Park DeWitt J, Kim YH, Han JH, Lee SH, Kim IH, Choe G et al (2012) Primary intracranial germ cell tumor originating from septum pellucidum that mimics central neurocytoma. J Clin Oncol 30(27):e274-277. https://doi.org/10.1200/jco.2012.42.4176
Piette C, Hoyoux C, Luckers O, Tebache M (2015) Atypical location of intracranial germinoma: a case report. Clin Neuroradiol 25(1):79–82. https://doi.org/10.1007/s00062-013-0274-2
Boukobza M, Polivka M (2019) Bifocal germinoma of the septum pellucidum and the sellar-supra-sellar region: an uncommon presentation for a rare tumor. ENeurologicalsci 15:100187. https://doi.org/10.1016/j.ensci.2019.100187
Sethi RV, Marino R, Niemierko A, Tarbell NJ, Yock TI, MacDonald SM (2013) Delayed diagnosis in children with intracranial germ cell tumors. J Pediatr 163(5):1448–1453. https://doi.org/10.1016/j.jpeds.2013.06.024
Phi JH, Kim SK, Lee YA, Shin CH, Cheon JE, Kim IO et al (2013) Latency of intracranial germ cell tumors and diagnosis delay. Childs Nerv Syst 29(10):1871–1881. https://doi.org/10.1007/s00381-013-2164-y
Takami H, Graffeo CS, Perry A, Giannini C, Daniels DJ (2020) Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors. J Neurosurg 7:1–9. https://doi.org/10.3171/2019.10.Jns191136
Kanamori M, Takami H, Yamaguchi S, Sasayama T, Yoshimoto K, Tominaga T et al (2021) So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma? Neuro Oncol 23(2):295–303. https://doi.org/10.1093/neuonc/noaa199
Kato T, Sawamura Y, Tada M, Murata J, Abe H, Shirato H et al (1998) Occult neurohypophyseal germinomas in patients presenting with central diabetes insipidus. Neurosurg Focus 5(1):e6. https://doi.org/10.3171/foc.1998.5.1.9
Yang P, Li L, Kuang W, Li B, Zhou B, Yang J et al (2014) Intracranial multiple germ cell tumors: a case report and review of literature. Int J Clin Exp Pathol 7(12):9002–9007
Aihara Y, Watanabe S, Amano K, Komatsu K, Chiba K, Imanaka K et al (2018) Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. J Neurosurg 131(3):687–694. https://doi.org/10.3171/2018.3.JNS172520