Intra‐cortical myelin mediates personality differences

Journal of Personality - Tập 87 Số 4 - Trang 889-902 - 2019
Nicola Toschi1,2, Luca Passamonti3,4
1Department of Biomedicine & Prevention University “Tor Vergata” Rome Italy
2Department of Radiology, Martinos Center for Biomedical Imaging, Boston, Massachusetts
3Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
4Institute of Bioimaging & Molecular Physiology National Research Council Milano Italy

Tóm tắt

AbstractObjectiveDifferences in myelination in the cortical mantle are important neurobiological mediators of variability in cognitive, emotional, and behavioral functioning. Past studies have found that personality traits reflecting such variability are linked to neuroanatomical and functional changes in prefrontal and temporo‐parietal cortices. Whether these effects are partially mediated by the differences in intra‐cortical myelin remains to be established.MethodTo test this hypothesis, we employed vertex‐wise intra‐cortical myelin maps in n = 1,003 people from the Human Connectome Project. Multivariate regression analyses were used to test for the relationship between intra‐cortical myelin and each of the five‐factor model’s personality traits, while accounting for age, sex, intelligence quotient, total intracranial volume, and the remaining personality traits.ResultsNeuroticism negatively related to frontal‐pole myelin and positively to occipital cortex myelin. Extraversion positively related to superior parietal myelin. Openness negatively related to anterior cingulate myelin, while Agreeableness positively related to orbitofrontal myelin. Conscientiousness positively related to frontal‐pole myelin and negatively to myelin content in the dorsal anterior cingulate cortex.ConclusionsIntra‐cortical myelin levels in brain regions with prolonged myelination are positively associated with personality traits linked to favorable outcome measures. These findings improve our understanding of the neurobiological underpinnings of variability in common behavioral dispositions.

Từ khóa


Tài liệu tham khảo

10.1002/mrm.25198

10.1002/hbm.23481

10.1002/hbm.23065

10.1016/j.neuroimage.2012.10.009

10.1111/j.1467-6494.2007.00485.x

10.1073/pnas.1010356107

Corr P., 2006, Understanding biological psychology

10.1017/pen.2017.1

Costa P. T., 1992, Revised NEO Personality Inventory (NEO‐PI‐R) and NEO Five‐Factor Inventory (NEO‐FFI) professional manual

10.1006/nimg.1998.0395

10.1016/j.jrp.2014.07.004

10.1016/j.neuroimage.2017.12.087

10.1111/j.1467-6494.2007.00438.x

10.1017/pen.2018.8

10.1002/per.2013

10.1093/cercor/bhg093

10.1523/JNEUROSCI.21-17-j0002.2001

10.1002/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4

10.1093/cercor/bht201

10.3389/fnhum.2014.00671

10.1016/j.neuroimage.2013.04.127

10.1523/JNEUROSCI.2180-11.2011

10.1523/JNEUROSCI.2811-13.2013

10.1016/j.neuroimage.2006.07.036

10.1016/j.cub.2009.12.038

10.3758/CABN.9.1.1

10.1002/dneu.22552

10.1073/pnas.1001229107

10.1523/JNEUROSCI.2531-12.2012

10.1034/j.1600-0447.2000.102004265.x

10.1002/hbm.22108

10.1037/0278-6133.27.5.505

10.1016/S0140-6736(01)01429-5

10.1016/S0006-3223(02)01817-6

Markett S., Network Neuroscience and Personality, Personality Neuroscience, 1

10.1037/0022-3514.88.3.547

10.1093/acprof:oso/9780195082944.001.0001

10.1073/pnas.1117943109

10.1002/ana.25019

10.1007/s00429-012-0460-z

10.1037/0022-3514.93.1.116

10.1016/j.tics.2005.03.010

10.1146/annurev.psych.57.102904.190127

10.1002/ajpa.20289

10.1016/j.neuroimage.2014.09.017

10.1038/mp.2008.65

Riccelli R., 2017, Surface‐based morphometry reveals the neuroanatomical basis of the five‐factor model of personality, Social Cognitive and Affective Neuroscience, 12, 671

Riley E. N., 2017, Towards a developmentally integrative model of personality change: A focus on three potential mechanisms, Advances in Psychology Research, 124, 63

10.1093/scan/nsr017

10.1037/0022-3514.81.4.670

10.1037/a0031109

10.1111/j.1467-8721.2008.00543.x

10.1002/hbm.23624

10.1002/hbm.24195

10.1038/s41598-017-02062-y

10.1016/j.neuroimage.2004.03.032

10.1016/j.neuroimage.2014.10.054

10.1109/42.668698

10.1037/pspp0000137

10.1016/j.jrp.2016.05.001

10.1016/S0191-8869(03)00035-7

10.1001/jamapsychiatry.2017.2816

10.1177/1073191117691844

10.1017/pen.2018.4

10.1017/pen.2017.2

10.1016/S1474-4422(18)30245-X

10.1016/j.neuroimage.2013.05.041

10.1002/hbm.24054

10.1016/j.heliyon.2017.e00411

10.1207/S15327752JPA7603_04

Thông tin
Thông tin xuất bản

Journal of Personality

Tập 87 Số 4

889-902

Thông tin tác giả