Intestinal Transport During Fasting and Malnutrition

Annual Review of Nutrition - Tập 20 Số 1 - Trang 195-219 - 2000
Ronaldo P. Ferraris1, Hannah V. Carey2
1Department of Pharmacology and Physiology, UMD-New Jersey Medical School, Newark, New Jersey 07103-2714, USA. [email protected]
2Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706

Tóm tắt

Fasting or malnutrition (FM) has dramatic effects on small intestinal mucosal structure and transport function. Intestinal secretion of ions and fluid is increased by FM both under basal conditions and in response to secretory agonists. Intestinal permeability to ions and macromolecules may also be elevated by FM, which increases the potential for fluid and electrolyte losses and for anaphylactic responses to luminal antigens. Mucosal atrophy induced by FM reduces total intestinal absorption of nutrients, but nutrient absorption normalized to mucosal mass may actually be enhanced by a variety of mechanisms, including increased transporter gene expression, electrochemical gradients, and ratio of mature to immature cells. These observations underscore the value of enteral feeding during health and disease.

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Annual Review of Nutrition

Tập 20 Số 1

195-219

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