Internalized Antigens Must Be Removed to Prepare Hypoimmunogenic Mesenchymal Stem Cells for Cell and Gene Therapy

Molecular Therapy - Tập 9 - Trang 747-756 - 2004
Jeffrey L. Spees1, Carl A. Gregory1, Harpreet Singh1, H.Alan Tucker1, Alexandra Peister1, Patrick J. Lynch1, Shu-Ching Hsu1, Jason Smith1, Darwin J. Prockop1
1Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA

Tài liệu tham khảo

Colter, 2000, Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow, Proc. Natl. Acad. Sci. USA, 97, 3213, 10.1073/pnas.97.7.3213 Sekiya, 2002, Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality, Stem Cells, 20, 530, 10.1634/stemcells.20-6-530 Keating, 1990, Effect of different promoters on expression of genes introduced into hematopoietic and marrow stromal cells by electroporation, Exp. Hematol, 18, 99 Schwarz, 1999, Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease, Hum. Gene Ther, 10, 2539, 10.1089/10430349950016870 Zhang, 2002, Lentiviral vectors for sustained transgene expression in human bone marrow-derived stromal cells, Mol. Ther, 5, 555, 10.1006/mthe.2002.0585 Baxter, 2002, Retrovirally mediated correction of bone marrow-derived mesenchymal stem cells from patients with mucopolysaccharidosis type I, Blood, 99, 1857, 10.1182/blood.V99.5.1857 Prockop, 1997, Marrow stromal cells as stem cells for nonhematopoietic tissues, Science, 276, 71, 10.1126/science.276.5309.71 Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143 Kopen, 1999, Marrow stromal cells migrate throughout the forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains, Proc. Natl. Acad. Sci. USA, 96, 10711, 10.1073/pnas.96.19.10711 Liechty, 2000, Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep, Nat. Med, 6, 1282, 10.1038/81395 Kotton, 2001, Bone marrow-derived cells as progenitors of lung alveolar epithelium, Development, 128, 5181, 10.1242/dev.128.24.5181 Toma, 2002, Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart, Circulation, 105, 93, 10.1161/hc0102.101442 Jiang, 2002, Pluripotency of mesenchymal stem cells derived from adult marrow, Nature, 418, 41, 10.1038/nature00870 Horwitz, 1999, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta, Nat. Med, 5, 309, 10.1038/6529 Horwitz, 2002, Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone, Proc. Natl. Acad. Sci. USA, 99, 8932, 10.1073/pnas.132252399 Koç, 2002, Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH), Bone Marrow Transplant, 30, 215, 10.1038/sj.bmt.1703650 Koç, 2000, Rapid hematopoietic recovery after co-infusion of autologous culture-expanded human mesenchymal stem cells (hMSCs) and PBPCs in breast cancer patients receiving high dose chemotherapy, J. Clin. Oncol, 18, 1824, 10.1200/JCO.2000.18.9.1824 Mackensen, 2000, Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells, Cancer Immunol. Immunother, 49, 152, 10.1007/s002620050614 Selvaggi, 1997, Development of antibodies to fetal calf serum with arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions, Blood, 89, 776, 10.1182/blood.V89.3.776 Tuschong, 2002, Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy, Hum. Gene Ther, 13, 1605, 10.1089/10430340260201699 Javazon, 2001, Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells, Stem Cells, 19, 219, 10.1634/stemcells.19-3-219 Buchner, 1947, Über ein phosphatübertragendes Garungsferment, Biochim. Biophys. Acta, 1, 292, 10.1016/0006-3002(47)90143-1 Adams, 1963, Adenosine 5′-triphosphate determination with phosphoglycerate kinase, 539