Intermittent oral trimethoprim/sulfamethoxazole on two non‐consecutive days per week is effective as Pneumocystis jiroveci pneumonia prophylaxis in pediatric patients receiving chemotherapy or hematopoietic stem cell transplantation

Pediatric Blood and Cancer - Tập 52 Số 1 - Trang 142-144 - 2009
Yasuhisa Ohata1, Hideaki Ohta2, Yoshiko Hashii1, Sadao Tokimasa1, Keiichi Ozono1, Junichi Hara3
1Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
2Department of Pediatrics, Osaka University Graduate School of Medicine, Yamadaoka 2‐2, Suita 565‐0871, Japan.
3Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan

Tóm tắt

AbstractPneumocystis jiroveci pneumonia (PCP) is a serious complication in patients receiving chemotherapy or hematopoietic stem cell transplantation. Current recommendations for trimethoprim‐sulfamethoxazole (TMP‐SMZ) dosing as PCP prophylaxis in immunocompromised patients are based on either daily dosing or dosing three consecutive days per week. We report our experience of prophylaxis with TMP‐SMZ twice daily on two non‐consecutive days per week in 145 immunocompromised children with hematologic disorders, cancer, or metabolic disorders following chemotherapy or hematopoietic stem cell transplantation. There were no breakthrough cases of PCP. We therefore conclude our prophylaxis regimen is effective against PCP in immunocompromised children. Pediatr Blood Cancer 2009;52:142–144. © 2008 Wiley‐Liss, Inc.

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Pediatric Blood and Cancer

Tập 52 Số 1

142-144

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