Interleukin‐8, a chemotactic and inflammatory cytokine

FEBS Letters - Tập 307 Số 1 - Trang 97-101 - 1992
Marco Baggiolini1, Ian Clark‐Lewis2
1Theodor-Kocher Institute, University of Bern, Bern, Switzerland
2The Biomedical Research Centre and Department of Biochemistry, University of British Columbia, Vancouver, Canada

Tóm tắt

Interleukin‐8 (IL‐8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin‐1 or tumor necrosis factor) and activates neutrophils inducing, chemotaxis, exocytosis and the respiratory burst. In vivo, IL‐8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil‐activating cytokines similar to IL‐8 in structure and function have been identified recently. IL‐8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local noutrophil accumulation.

Từ khóa


Tài liệu tham khảo

10.1172/JCI114265

10.1073/pnas.88.2.502

10.1016/S0021-9258(19)40094-X

10.1084/jem.171.4.1155

10.1016/0006-291X(90)91929-M

10.1016/S0021-9258(18)45315-X

Baggiolini M., 1992, News Physiol. Sci., 8

10.1096/fasebj.2.11.2840318

Colditz I., 1989, Am. J. Pathol., 134, 755

10.1002/jlb.48.2.129

10.1111/1523-1747.ep12470612

10.1111/1523-1747.ep12470606

10.1165/ajrcmb/2.6.479

10.1084/jem.173.3.771

Baggiolini M. Dewald B. and Walz A. in: Inflammation. Basic Principles and Clinical Correlates 2nd Ed. (J.I. Gallin I.M. Goldstein and R. Snyderman eds ) Raven Press New York in press.

10.1172/JCI115018

10.1084/jem.171.2.449

10.1002/j.1460-2075.1988.tb03042.x

10.1084/jem.171.5.1797

10.1073/pnas.87.19.7732

10.1084/jem.174.6.1355

10.1007/BF00208938

10.1084/jem.167.5.1547

10.1016/S0021-9258(18)99275-6

10.1084/jem.169.3.1185

10.1016/0006-291X(90)91143-G

10.1126/science.1840701

10.1126/science.1891716

10.1016/0167-5699(91)90142-G

10.1016/S0021-9258(18)54472-0

10.1016/S0021-9258(18)55160-7

10.1111/1523-1747.ep12514689

Nickoloff B.J., 1991, Am. J. Pathol., 138, 129

10.1111/1523-1747.ep12495817

10.1111/1523-1747.ep12478128

10.1002/eji.1830200938

10.1042/bj2590585

10.1016/1043-4666(90)90004-D

Thông tin
Thông tin xuất bản

FEBS Letters

Tập 307 Số 1

97-101

Thông tin tác giả