Interleukin‐17 as an Effector Molecule of Innate and Acquired Immunity against Infections

Microbiology and Immunology - Tập 51 Số 12 - Trang 1139-1147 - 2007
Goro Matsuzaki1, Masayuki Umemura1
1Molecular Microbiology Group, Center of Molecular Biosciences, and Division of Host Defense and Vaccinology Graduate School of Medicine, University of the Ryukyus Okinawa 903‐0213 Japan

Tóm tắt

AbstractInterleukin (IL)‐17 is a proinflammatory cytokine which induces differentiation and migration of neutrophils through induction of cytokines and chemokines including granulocyte‐colony stimulating factor and CXCL8/IL‐8. IL‐17‐producing CD4+ T cells (Th17) have pivotal role in pathogenesis of autoimmune diseases. IL‐17 is also involved in protective immunity against various infections. IL‐17 has important role in induction of neutrophil‐mediated protective immune response against extracellular bacterial or fungal pathogens such as Klebsiella pneumoniae and Candida albicans. Importance of IL‐17 in protection against intracellular pathogens including Mycobacterium has also been reported. Interestingly, not only CD4+ T cells but atypical CD4–CD8– T cells expressing T cell receptor (TCR) γδ produce IL‐17, and IL‐17 producing cells participate in both innate and acquired immune response to infections. Furthermore, neutrophil induction may not be the only mechanism of IL‐17‐mediated protective immunity. IL‐17 seems to participate in host defense through regulation of cell‐mediated immunity or induction of antimicrobial peptides such as β‐defensins. In this review, we summarize recent progress on the role of IL‐17 in immune response against infections, and discuss possible application of IL‐17 in prevention and treatment of infectious diseases.

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Tài liệu tham khảo

10.1038/ni1467

10.1038/ni1375

10.4049/jimmunol.170.4.1958

10.4049/jimmunol.168.3.1322

10.4049/jimmunol.177.3.1416

10.1152/ajplung.00312.2006

10.4049/jimmunol.170.9.4432

10.1084/jem.20050193

10.1128/IAI.73.9.5782-5788.2005

10.1038/ni1254

10.4049/jimmunol.177.11.7980

10.1086/422329

10.4049/jimmunol.165.11.6107

10.1128/IAI.73.1.617-621.2005

10.4049/jimmunol.175.2.788

10.1038/ni1449

10.4049/jimmunol.176.2.1098

Knappe A., 1998, The interleukin‐17 gene of herpesvirus Saimiri, J. Virol., 72, 5797, 10.1128/JVI.72.7.5797-5801.1998

10.1111/j.1574-695X.2006.00210.x

10.1038/ni1460

10.1016/j.immuni.2007.03.014

10.1084/jem.20061308

10.4049/jimmunol.177.7.4662

10.4049/jimmunol.165.9.5332

10.4049/jimmunol.169.10.5897

10.1038/nature04754

10.1084/jem.20061551

10.1016/S1359-6101(03)00002-9

10.1016/S1074-7613(02)00391-6

10.1038/ni1261

10.1006/viro.2002.1400

10.1128/IAI.01329-06

10.1074/jbc.M606542200

10.1084/jem.20061775

10.4049/jimmunol.178.7.4466

10.1128/JVI.01877-06

10.1016/j.immuni.2005.01.011

10.1038/ni1376

10.1093/intimm/dxh111

10.4049/jimmunol.178.6.3786

10.1016/j.immuni.2006.01.001

10.1073/pnas.0400983101

10.1016/j.immuni.2006.06.002

10.1016/j.micinf.2006.10.012

10.1016/1074-7613(95)90070-5

10.1165/ajrcmb.25.3.4424

10.1084/jem.194.4.519

10.1182/blood-2005-09-010116

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Thông tin xuất bản

Microbiology and Immunology

Tập 51 Số 12

1139-1147

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