Interleukin-10 haplotypes in Celiac Disease in the Spanish population
Tóm tắt
Celiac disease (CD) is a chronic disorder characterized by a pathological inflammatory response after exposure to gluten in genetically susceptible individuals. The HLA complex accounts for less than half of the genetic component of the disease, and additional genes must be implicated. Interleukin-10 (IL-10) is an important regulator of mucosal immunity, and several reports have described alterations of IL-10 levels in celiac patients. The
A case-control and a familial study were performed. Positions -1082, -819 and -592 of the
No significant associations after Bonferroni correction were observed in the SNPs or any of the microsatellites. Stratification by HLA-DQ2 (DQA1*0501-DQB1*02) status did not alter the results. When extended haplotypes were analyzed, no differences were apparent either.
The
Từ khóa
Tài liệu tham khảo
Jabri B, Kasarda DD, Green PH: Innate and adaptive immunity: the yin and yang of celiac disease. Immunol Rev. 2005, 206: 219-231. 10.1111/j.0105-2896.2005.00294.x.
Bevan S, Popat S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K, Ferguson A, Godkin A, Hogberg L, Holmes G, Hosie KB, Howdle PD, Jenkins H, Jewell D, Johnston S, Kennedy NP, Kerr G, Kumar P, Logan RF, Love AH, Marsh M, Mulder CJ, Sjoberg K, Stenhammer L, Walker-Smith J, Marossy AM, Houlston RS: Contribution of the MHC region to the familial risk of coeliac disease. J Med Genet. 1999, 36 (9): 687-690.
Nilsen EM, Jahnsen FL, Lundin KE, Johansen FE, Fausa O, Sollid LM, Jahnsen J, Scott H, Brandtzaeg P: Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology. 1998, 115 (3): 551-563. 10.1016/S0016-5085(98)70134-9.
Hahn-Zoric M, Hytonen AM, Hanson LA, Nilsson LA, Padyukov L: Association of -1087 IL10 and -308 TNFA gene polymorphisms with serological markers of coeliac disease. J Clin Immunol. 2003, 23 (4): 291-296. 10.1023/A:1024588800754.
Salvati VM, Mazzarella G, Gianfrani C, Levings MK, Stefanile R, De Giulio B, Iaquinto G, Giardullo N, Auricchio S, Roncarolo MG, Troncone R: Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa. Gut. 2005, 54 (1): 46-53. 10.1136/gut.2003.023150.
Li MC, He SH: IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J Gastroenterol. 2004, 10 (5): 620-625.
Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW: Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci U S A. 1998, 95 (16): 9465-9470. 10.1073/pnas.95.16.9465.
Martinez Doncel A, Rubio A, Arroyo R, de las Heras V, Martin C, Fernandez-Arquero M, de la Concha EG: Interleukin-10 polymorphisms in Spanish multiple sclerosis patients. J Neuroimmunol. 2002, 131 (1–2): 168-172. 10.1016/S0165-5728(02)00248-5.
Martinez A, Pascual M, Pascual-Salcedo D, Balsa A, Martin J, de la Concha EG: Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study. Genes Immun. 2003, 4 (2): 117-121. 10.1038/sj.gene.6363931.
Urcelay E, Santiago JL, de la Calle H, Martinez A, Figueredo A, Fernandez-Arquero M, de la Concha EG: Interleukin-10 polymorphisms in Spanish type 1 diabetes patients. Genes Immun. 2004, 5 (4): 306-309. 10.1038/sj.gene.6364071.
Fernandez L, Martinez A, Mendoza JL, Urcelay E, Fernandez-Arquero M, Garcia-Paredes J, Diaz-Rubio M, de la Concha EG: Interleukin-10 polymorphisms in Spanish patients with IBD. Inflamm Bowel Dis. 2005, 11 (8): 739-743. 10.1097/01.MIB.0000173457.64868.20.
Cantor MJ, Nickerson P, Bernstein CN: The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. Am J Gastroenterol. 2005, 100 (5): 1134-1142. 10.1111/j.1572-0241.2005.40979.x.
Woolley N, Mustalahti K, Maki M, Partanen J: Cytokine gene polymorphisms and genetic association with coeliac disease in the Finnish population. Scand J Immunol. 2005, 61 (1): 51-56. 10.1111/j.0300-9475.2005.01525.x.
Lio D, Scola L, Forte GI, Accomando S, Giacalone A, Crivello A, Cataldo F: TNFalpha, IFNgamma and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease. Dig Liver Dis. 2005, 37 (10): 756-760. 10.1016/j.dld.2005.04.027.
Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990, 65 (8): 909-911.
De la Concha EG, Fernandez-Arquero M, Gual L, Vigil P, Martinez A, Urcelay E, Ferreira A, Garcia-Rodriguez MC, Fontan G: MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes. J Immunol. 2002, 169 (8): 4637-4643.
[http://calculators.stat.ucla.edu/powercalc/]
Eskdale J, Keijsers V, Huizinga T, Gallagher G: Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immun. 1999, 1 (2): 151-155. 10.1038/sj.gene.6363656.
Cataldo F, Lio D, Marino V, Scola L, Crivello A, Corazza GR: Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. Pediatr Allergy Immunol. 2003, 14 (4): 320-324. 10.1034/j.1399-3038.2003.00053.x.
Mizrachi A, Broide E, Buchs A, Kornberg A, Aharoni D, Bistritzer T, Rapoport MJ: Lack of correlation between disease activity and decreased stimulated secretion of IL-10 in lymphocytes from patients with celiac disease. Scand J Gastroenterol. 2002, 37 (8): 924-930. 10.1080/003655202760230883.
Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarstrom S, Hammarstrom ML: Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology. 2002, 123 (3): 667-678. 10.1053/gast.2002.35355.
Garrote J, Arranz E, Gomez-Gonzalez E, Leon A, Farre C, Calvo C, Bernardo D, Fernandez-Salazar L, Blanco-Quiros A: IL6, IL10 and TGFB1 gene polymorphisms in coeliac disease: differences between DQ2 positive and negative patients. Allergol Immunopathol (Madr). 2005, 33 (5): 245-249. 10.1157/13080926.
Cataldo F, Lio D, Marino V, Scola L, Crivello A, Mule AM, Corazza GR: Cytokine genotyping (TNF and IL-10) in patients with celiac disease and selective IgA deficiency. Am J Gastroenterol. 2003, 98 (4): 850-856. 10.1111/j.1572-0241.2003.t01-1-07377.x.
de la Concha EG, Fernandez-Arquero M, Vigil P, Rubio A, Maluenda C, Polanco I, Fernandez C, Figueredo MA: Celiac disease and TNF promoter polymorphisms. Hum Immunol. 2000, 61 (5): 513-517. 10.1016/S0198-8859(99)00187-1.
Henkel G, Weiss DL, McCoy R, Deloughery T, Tara D, Brown MA: A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J Immunol. 1992, 149 (10): 3239-3246.
Fujioka M, Emi-Sarker Y, Yusibova GL, Goto T, Jaynes JB: Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients. Development. 1999, 126 (11): 2527-2538.
Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV: An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 1997, 24 (1): 1-8.