Interleukin 1 causing bone destruction in middle ear cholesteatoma

Otolaryngology - Head and Neck Surgery - Tập 103 Số 4 - Trang 527-536 - 1990
Jeffrey Ahn1, Cheng‐Chun Huang1, Maxwell Abramson1
1Department of Otolaryngology Columbia University New York New York

Tóm tắt

We previously reported the localization of interleukin 1 in the epithelial layer of human cholesteatomas. On the basis of other studies that showed interleukin 1 can stimulate fibroblasts and macrophages to produce collagenases and prostaglandins, we then proposed that interleukin 1 may play an important role in cholesteatoma‐related bone resorption, also. Our immunocytochemical study involving more human cholesteatoma samples revealed the presence of interleukin 1 in bone cells and monocytes in the region of active bone destruction. In the present study, the effect of interleukin 1 on these cells found at the bone resorption site was examined. By radioimmunoassay, interleukin 1 was shown to stimulate the production of prostaglandin E2 by osteoblasts in vitro. Interleukin 1 also promoted the migration and multinucleation of bone marrow‐derived monocytes. These osteoclast‐like cells formed from monocytes contained tartrate‐resistant acid phosphatase, and caused the resorption of the devitalized bone in vitro. Above findings suggest that interleukin 1 could cause the bone destruction in cholesteatomas, not only by stimulating the local bone cells, but also by recruiting monocytes for osteoclastic bone resorption.

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Tài liệu tham khảo

10.1002/lary.5540940117

10.1017/S0022215100054396

10.1177/000348946907800110

Thomsen J, 1977, Proceedings of the first international conference in cholesteatoma, 136

10.1001/archotol.1987.01860040048015

10.1177/000348948809700615

Dewhirst FE, 1985, Purification and partial sequence of human osteoclast‐activating factor: Identity with interleukin 1 beta, J Immunol, 135, 2562, 10.4049/jimmunol.135.4.2562

10.1084/jem.157.2.801

10.1016/0196-0709(90)90001-C

10.1007/BF02411252

Nisbet JA, 1970, Relation of lactic and citric acid metabolism to bone resorption in tissue culture, Clin Orthopedics, 70, 220

10.1172/JCI107696

10.1083/jcb.39.3.676

10.1083/jcb.101.6.2210

10.1002/ar.1092040103

10.1016/0014-4827(65)90050-9

10.1042/bj1370387

10.1083/jcb.102.4.1164

10.1172/JCI113316

10.4049/jimmunol.125.3.1302

10.1210/endo-86-6-1436

Raisz LG, 1984, Bone and mineral research, 286

10.1002/path.1711390313

10.1172/JCI112141

10.1084/jem.164.6.2095

10.1017/S0022215100078476

Tos M, 1979, Pathology of the ossicular chain in various chronic middle ear disease, J Otolaryngol, 93, 769

Thông tin
Thông tin xuất bản

Otolaryngology - Head and Neck Surgery

Tập 103 Số 4

527-536

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