Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

American Association for the Advancement of Science (AAAS) - Tập 240 Số 4851 - Trang 516-518 - 1988
Yasuhiro Suzuki1, Manuel Orellana1, Robert D. Schreiber2,3, Jack S. Remington1
1Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, CA 94301 and Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305.
2Departnent of Pathology, Washington University School of Medicine, St. Louis, MO 63130.
3Immunobiology

Tóm tắt

Mice were injected with a monoclonal antibody to interferon-γ to examine the importance of endogenous production of this lymphokine in resistance against infection with the sporozoan parasite Toxoplasma gondii . Mice with intraperitoneal infections of T. gondii that received no antibody survived and developed chronic T. gondii infection, whereas the infected mice that received the monoclonal antibody died of toxoplasmosis. The activation of macrophages, which kill T. gondii in vivo, was inhibited by administration of the monoclonal antibody, but the production of antibodies to T. gondii was not suppressed. The fact that an antibody to interferon-γ can eliminate resistance to acute Toxoplasma infection in mice suggests that this lymphokine is an important mediator of host resistance to this parasite.

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American Association for the Advancement of Science (AAAS)

Tập 240 Số 4851

516-518

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