Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells

Science immunology - Tập 4 Số 33 - 2019
Fella Tamzalit1, Mitchell S. Wang2, Weiyang Jin3, María Tello‐Lafoz1, Vitaly Boyko4, John M. Heddleston5, Charles T. Black6, Lance C. Kam3, Morgan Huse1
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
2Pharmacology Graduate Program, Weill Cornell Medical College, New York, NY, USA.
3Department of Biomedical Engineering, Columbia University, New York, NY, USA
4Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA
5Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
6Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.

Tóm tắt

Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing.

Từ khóa


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Science immunology

Tập 4 Số 33

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