Intercellular Transport of MicroRNAs

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 33 Số 2 - Trang 186-192 - 2013
Reinier A. Boon1, Kasey C. Vickers2,1
1From the Institute for Cardiovascular Regeneration, J.W. Goethe University Hospital, Frankfurt am Main, Germany (R.A.B.); and Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (K.C.V.).
2Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 358B PRB, Nashville, TN 37232.

Tóm tắt

Extracellular microRNAs (miRNA) are present in most biological fluids, relatively stable, and hold great potential for disease biomarkers and novel therapeutics. Circulating miRNAs are transported by membrane-derived vesicles (exosomes and microparticles), lipoproteins, and other ribonucleoprotein complexes. Evidence suggests that miRNAs are selectively exported from cells with distinct signatures that have been found to be altered in many pathophysiologies, including cardiovascular disease. Protected from plasma ribonucleases by their carriers, functional miRNAs are delivered to recipient cells by various routes. Transferred miRNAs use cellular machinery to reduce target gene expression and alter cellular phenotype. Similar to soluble factors, miRNAs mediate cell-to-cell communication linking disparate cell types, diverse biological mechanisms, and homeostatic pathways. Although significant advances have been made, miRNA intercellular communication is full of complexities and many questions remain. This review brings into focus what is currently known and outstanding in a novel field of study with applicability to cardiovascular disease.

Từ khóa


Tài liệu tham khảo

10.1038/nature07242

10.1016/S0092-8674(04)00045-5

10.1016/j.cell.2009.01.002

10.1101/gr.082701.108

10.1097/MOL.0b013e3283428d9d

10.1016/j.tem.2010.08.008

10.1038/nature09783

10.1016/j.cell.2012.02.005

10.1073/pnas.0804549105

10.1186/1758-907X-1-7

10.1371/journal.pone.0030679

10.1111/j.1349-7006.2010.01650.x

10.1016/j.urolonc.2009.01.027

10.1373/clinchem.2011.169714

10.3233/JAD-2008-14103

10.1371/journal.pone.0034566

10.1016/j.ceb.2009.03.007

10.3410/B3-15

10.1097/MOL.0b013e328350a425

10.1373/clinchem.2003.028506

10.1111/j.1365-2141.2008.07077.x

10.1007/BF00039378

10.1038/39215

10.1016/j.molcel.2010.06.010

10.1038/ncb1596

10.1038/ncb2210

10.1038/nri855

10.1161/circresaha.110.226456

10.1126/scisignal.2000610

10.1111/j.1365-2141.1967.tb08741.x

10.1073/pnas.1019055108

10.1093/nar/gkr254

10.1371/journal.pone.0011803

10.1371/journal.pone.0031952

10.1038/ncb1800

10.3816/CLC.2009.n.001

10.1016/j.mcn.2010.11.004

Vrijsen KR, Sluijter JP, Schuchardt MW, van Balkom BW, Noort WA, Chamuleau SA, Doevendans PA. Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells. J Cell Mol Med. 2010;14:1064–1070.

10.1161/CIRCGENETICS.110.958975

10.1016/S0008-6363(03)00367-5

10.1182/blood.V94.11.3791

10.1038/ni854

10.1016/j.mrfmmm.2011.03.004

10.1161/circresaha.109.215566

10.1161/ATVBAHA.111.226696

Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2012;<Volume>:.

10.1093/nar/gkq601

10.1371/journal.pone.0013247

10.1371/journal.pone.0013515

10.1038/ncomms1285

10.1074/jbc.M110.107821

10.1002/hep.24504

10.1126/science.1153124

10.1007/s12017-010-8120-z

10.1128/JVI.05853-11

10.1073/pnas.1014194107

10.1073/pnas.0914843107

10.4161/cib.3.5.12339

10.1158/0008-5472.CAN-11-0241

10.1038/emboj.2012.183

10.1038/ncb2441

10.1073/pnas.1209414109

10.1016/j.cellsig.2011.03.013

10.1016/j.bbrc.2010.07.008

10.1095/biolreprod.108.075481

10.1371/journal.pone.0004722

10.1038/cr.2008.282

10.1002/hep.22569

10.1161/circresaha.110.226357

10.1016/j.pharmthera.2010.12.003

Zhang L, Hou D, Chen X, et al.. Exogenous plant mir168a specifically targets mammalian ldlrap1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2011

10.1038/nbt1339

10.1593/neo.101372

10.4161/cib.3.5.12693

10.1038/ncb1929

10.1038/ncb1930

10.1093/nar/gkp857

10.1126/science.271.5248.518

10.1182/blood-2011-02-338004

10.1182/blood-2004-03-0824

10.1002/jcb.22733

10.1074/jbc.M109.041152

Thông tin
Thông tin xuất bản

Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 33 Số 2

186-192

Thông tin tác giả