Interactions between CYP3A4 and Dietary Polyphenols

Oxidative Medicine and Cellular Longevity - Tập 2015 - Trang 1-15 - 2015
Loai Basheer1, Zohar Kerem1
1Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100, Rehovot, Israel.

Tóm tắt

The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds. CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics. Dietary compounds, of which polyphenolics are the most studied, have been shown to interact with CYP3A4 and alter its expression and activity. Traditionally, the liver was considered the prime site of CYP3A-mediated first-pass metabolic extraction, butin vitroandin vivostudies now suggest that the small intestine can be of equal or even greater importance for the metabolism of polyphenolics and drugs. Recent studies have pointed to the role of gut microbiota in the metabolic fate of polyphenolics in human, suggesting their involvement in the complex interactions between dietary polyphenols and CYP3A4. Last but not least, all the above suggests that coadministration of drugs and foods that are rich in polyphenols is expected to stimulate undesirable clinical consequences. This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.

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Tài liệu tham khảo

10.1021/cr0307143

10.1021/bi010758a

10.1016/s0140-6736(02)11203-7

2005

2009, Human Genomics, 4, 59, 10.1186/1479-7364-4-1-59

10.1098/rstb.2012.0430

10.1098/rstb.2012.0431

10.1089/dna.1991.10.1

10.1016/j.pharmthera.2012.12.007

10.1021/tx700079z

10.1016/s0165-6147(03)00049-x

10.1172/jci119439

10.1097/00008571-199410000-00003

10.1016/j.tips.2011.08.005

10.1111/j.1528-1167.2010.02956.x

10.1146/annurev.pharmtox.39.1.1

1996, Drug Metabolism and Disposition, 24, 899

1999, Pharmacological Reviews, 51, 135

10.1124/dmd.105.008672

10.2133/dmpk.25.28

10.1016/j.clpt.2004.07.001

1997, Journal of Pharmacology and Experimental Therapeutics, 283, 1552

10.1124/dmd.113.051664

10.2174/138920013804545241

10.2174/138920008786049276

1999, Drug Metabolism and Disposition, 27, 161

10.1503/cmaj.120951

10.1124/dmd.110.032649

10.1073/pnas.1000098107

10.1017/s0007114510003946

10.1124/dmd.31.12.1520

10.1124/dmd.105.009035

10.1007/BF03190865

10.1007/s11095-006-9041-2

2014, Journal of Pharmacy and Pharmaceutical Sciences, 17, 1, 10.18433/J30K63

10.1021/mp300512r

10.1002/bit.22775

10.1016/j.bbrc.2004.08.141

10.1016/j.toxlet.2011.01.019

10.1016/j.bbrc.2012.12.072

10.1007/s11120-008-9322-1

10.1021/cr020443g

10.1007/0-387-27447-2_6

10.1080/03602530902843483

10.1124/dmd.104.003327

2001, Drug Metabolism & Disposition, 29, 1263

10.1517/17425255.3.3.389

10.1002/mnfr.200800516

10.1080/21551197.2012.698219

10.3390/molecules16021486

2000, Journal of Nutrition, 130, 2073S, 10.1093/jn/130.8.2073S

10.1021/mp700075m

10.1021/tx7000515

2014, EXCLI Journal, 13, 347

10.1016/s0955-2863(02)00208-5

10.2174/138955708783498131

10.1161/01.cir.102.9.1020

2008, The American Journal of Clinical Nutrition, 88, 38, 10.1093/ajcn/88.1.38

10.1007/s12263-009-0136-3

10.1038/nrc1189

10.1111/j.1750-3841.2011.02155.x

10.1111/j.1749-6632.2012.06510.x

10.1111/j.2042-7158.2012.01551.x

10.1016/j.bbapap.2010.09.014

10.1007/s10460-011-9332-z

2011, Journal of Pharmacy Research, 4, 986

10.1081/DMR-120018248

10.1111/j.1472-8206.2004.00301.x

10.2174/138920006778520598

10.1007/978-4-431-54992-5_4

10.1124/dmd.113.051094

10.1124/dmd.113.055236

10.1016/j.fct.2009.10.041

10.1002/ptr.2613

10.2165/00003088-200342130-00001

10.1046/j.1365-2125.1998.00764.x

10.1002/j.1552-4604.1998.tb04393.x

10.1097/00007890-199607150-00023

10.1001/jama.290.11.1500

10.1345/aph.10088

10.1158/1940-6207.CAPR-09-0155

10.1097/ftd.0b013e31815c16f5

10.2174/1389200211209050640

10.1155/2013/730734

10.1517/17425255.2012.680886

2005, Clinical Pharmacology & Therapeutics, 78, 19, 10.1016/j.clpt.2005.04.002

10.1097/01.mjt.0000101827.94820.22

10.1007/s13197-014-1472-x

10.1124/dmd.113.052563

10.1002/ptr.4782

10.1111/jcpt.12075

10.1124/dmd.107.018663

10.1124/dmd.32.2.259

10.1146/annurev.nutr.22.111401.144957

2005, The American Journal of Clinical Nutrition, 81, 215S, 10.1093/ajcn/81.1.215S

10.1007/978-3-642-30018-9_162

10.1017/s0954422413000097

2008, Journal of Nutrition, 138, 562, 10.1093/jn/138.3.562

10.3177/jnsv.50.203

10.1016/j.foodchem.2006.02.006

10.1016/s0891-5849(01)00718-3

10.1021/jf0621828

10.1016/S0955-2863(01)00155-3

10.1002/ejlt.201000044

10.1007/s10555-010-9236-1

10.1016/j.bcp.2006.02.009

10.1016/j.phrs.2003.12.003

10.1080/10408390591000541

10.1016/j.lfs.2005.12.006

10.1016/j.lwt.2010.01.016

10.1016/j.procbio.2011.12.004

2011, International Food Research Journal, 18, 529

10.1016/j.phymed.2012.12.011

10.5455/jeim.050913.or.089

10.1136/gutjnl-2014-307142

10.1016/S0891-5849(02)00877-8

1998, Nutrition Reviews, 56, 317

10.1016/s0300-483x(99)00215-2

10.2174/0929867013373011

10.1124/dmd.107.016410

10.1517/17425255.2012.681375

10.1016/j.phrs.2011.02.007

10.1007/s10822-010-9381-1

10.1517/17425250903158940

10.2133/dmpk.DMPK-13-NT-006

10.2133/dmpk.19.280

10.1016/j.jconrel.2011.09.083

10.1111/j.1749-6632.2010.05842.x

10.1124/jpet.102.033340

10.1111/jphp.12232

10.1002/jps.24114

10.1016/j.anaerobe.2013.07.009

10.1016/j.ijfoodmicro.2008.03.017

10.1016/j.copbio.2012.09.009

10.3945/ajcn.110.004945

10.3945/ajcn.2009.26736d

10.1002/mnfr.200900123

10.2165/00003088-200038010-00003

10.1016/s0027-5107(01)00204-4

10.1073/pnas.071042698

10.1016/j.phytochem.2009.10.020

10.1016/j.taap.2006.12.025

10.1517/17425255.2014.885017

10.1007/s13318-014-0203-z

10.1007/s11101-014-9358-0

10.1124/dmd.114.059451

10.1002/fsn3.122

10.1021/tx100286d

10.1007/bf00686195

10.1007/s12272-011-0411-x

10.1021/jf104786t

10.1111/j.1365-2125.1993.tb00396.x

10.1124/dmd.31.5.533

10.1097/fjc.0b013e3181ffe8d0

10.1016/j.ddtec.2012.09.011

10.1016/j.bcp.2007.11.012

10.1371/journal.pone.0083898

10.1042/bj20130398

10.1074/jbc.M111.325654

10.1074/jbc.m110.182055

10.1016/j.abb.2007.03.006

10.1055/s-2006-931537

10.2165/00003088-199426020-00002

10.1016/0009-9236(95)90048-9

2001, Journal of Pharmacy & Pharmaceutical Sciences, 4, 217

10.1124/dmd.110.032847

10.1016/j.jpba.2014.05.038

10.2133/dmpk.dmpk-12-rg-113

10.1078/094471103322004839

10.1021/tx9802320

10.1016/j.jsbmb.2008.10.001

10.3109/00498254.2011.615954

10.1007/s00228-010-0964-5

10.1002/mnfr.200800043

10.1016/S0024-3205(00)00888-2

10.1016/s0378-4274(01)00418-0

10.1111/j.1755-5922.2008.00060.x

10.1016/j.taap.2012.07.003

10.3109/03602532.2012.700715

2005, Inhibition of cytochrome P450 enzymes, 247

10.1021/tx960060b

10.1124/dmd.104.000646

2000, Drug Metabolism and Disposition, 28, 1270

10.1002/ptr.1000

10.1016/j.fct.2007.09.073

2011, Journal of Medicinal Plants Research, 5, 3530

2000, Journal of Nutrition, 130, 2367, 10.1093/jn/130.9.2367

10.1211/0022357021778303

10.1074/jbc.c400293200

10.1126/science.1099736

10.3390/molecules17089283

10.1016/S0300-483X(97)00159-5

1999, Journal of Pharmacology and Experimental Therapeutics, 291, 424

2001, Drug Metabolism and Disposition, 29, 936

10.1124/dmd.31.9.1108

2009, Anticancer Research, 29, 935

2001, Drug Metabolism and Disposition, 29, 1644

10.1073/pnas.0603236103

10.1016/j.pharmthera.2009.05.011

10.1146/annurev.pharmtox.45.120403.100004

10.1124/dmd.30.4.355

10.1517/17425250802500028

10.1016/j.abb.2011.12.017

10.1080/14756360600952183

10.1080/14756360500532747

10.1021/ci0600915

10.1016/j.jff.2014.06.026

10.1016/j.jep.2014.05.055

10.1111/apt.12109

10.1016/j.jep.2012.12.027

10.1155/2013/804086

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Oxidative Medicine and Cellular Longevity

Tập 2015

1-15

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