Biến thiên giữa các cá thể của các chỉ số sinh học về tiếp xúc với thủy ngân ở người: một đánh giá cắt ngang
Tóm tắt
Các chỉ số sinh học cho sự tiếp xúc với thủy ngân (Hg) đã thường xuyên được sử dụng để đánh giá mức độ tiếp xúc và rủi ro trong các nhóm dân số nói chung. Chúng tôi đã đánh giá các chỉ số sinh học thường được sử dụng nhất và sinh lý học mà chúng dựa vào, nhằm khám phá sự biến thiên giữa các cá thể và tính phù hợp của chúng trong việc đánh giá mức độ tiếp xúc.
Nồng độ của thủy ngân tổng (THg), thủy ngân vô cơ (IHg) và thủy ngân hữu cơ (OHg, được giả định là methylmercury; MeHg) đã được xác định trong máu toàn phần, hồng cầu, huyết tương, tóc và nước tiểu của nam và nữ Thụy Điển. Một hệ thống phân tích phổ huỳnh quang nguyên tử bằng hơi lạnh với nhiều lần tiêm tự động cho phân tích Hg đã được phát triển, cung cấp độ nhạy, độ chính xác và độ ổn định cao. Sự phân bố của các dạng thủy ngân khác nhau trong các môi trường sinh học khác nhau đã được khám phá.
Từ khóa
#thủy ngân #chỉ số sinh học #tiếp xúc #methylmercury #sinh lý họcTài liệu tham khảo
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