Institutionalization risk and costs associated with agitation in Alzheimer's disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 851-861 - 2019
Martin Cloutier1, Marjolaine Gauthier-Loiselle1, Patrick Gagnon-Sanschagrin1, Annie Guerin1, Ann Hartry2, Ross A. Baker3, Ruth Duffy3, Keva Gwin2, Myrlene Sanon Aigbogun3
1Analysis Group, Inc., Montreal, QC, Canada
2Lundbeck Pharmaceuticals, Deerfield, IL, USA
3Otsuka Pharmaceutical Development & Commercialization, Inc, Princeton, NJ, USA

Tóm tắt

AbstractIntroductionAgitation in individuals with Alzheimer's disease (AD) may predict institutionalization. This study assessed the incremental risk and costs associated with agitation in individuals with AD.MethodsA retrospective analysis of the National Alzheimer's Coordinating Center Uniform Data Set (June 2005–February 2018) was conducted. Incremental risk of institutionalization associated with agitation was estimated and used with the number of institutionalized individuals with AD and agitation and costs of living by residential setting in the United States (literature‐based), to estimate incremental institutionalization costs.ResultsThe analysis included 11,348 individuals with AD: 6603 (58.2%) with and 4745 (41.8%) without agitation. Compared with individuals without agitation, those with agitation were 20% more likely to be institutionalized (odds ratio = 1.20; 95% CI = 1.08–1.33). Total incremental cost of institutionalization associated with agitation was $4.3 billion ($50,588/individual).DiscussionAgitation is associated with a higher risk of institutionalization among patients with AD, which translates into a substantial economic burden.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 5

851-861

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