Mất ngủ và nguy cơ gặp phải các vấn đề cơ xương khớp mãn tính: dữ liệu theo chiều dọc từ nghiên cứu HUNT, Na Uy

BMC Musculoskeletal Disorders - Tập 19 - Trang 1-9 - 2018
B. L. Uhlig1, T. Sand1,2, T. I. Nilsen3,4, P. J. Mork3, K. Hagen1,2,5
1Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
2Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway
3Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
4Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim, Norway
5Norwegian Advisory Unit on Headaches, St. Olavs Hospital, Trondheim, Norway

Tóm tắt

Mục đích của nghiên cứu này là điều tra mối liên hệ tiềm năng giữa mất ngủ và nguy cơ mắc các vấn đề cơ xương khớp mãn tính (CMSC) và các vấn đề cơ xương khớp toàn thân mãn tính (CWMSC). Mục đích thứ hai là đánh giá mối liên hệ giữa mất ngủ và số vùng cơ thể gặp phải CMSC theo dõi. Chúng tôi đã sử dụng dữ liệu từ sóng thứ hai (HUNT2, 1995–1997) và sóng thứ ba (HUNT3, 2006–2008) của Nghiên cứu Sức khỏe Nord-Trøndelag (Nghiên cứu HUNT). Dân số có nguy cơ bao gồm 13.429 người trong độ tuổi từ 20–70 tuổi không báo cáo mắc CMSC tại điểm khởi đầu trong HUNT2 và đã trả lời bảng hỏi về mất ngủ trong HUNT2 và CMSC trong HUNT3. Mất ngủ được xác định theo ấn bản lần thứ 4 của Hướng dẫn chẩn đoán và thống kê các rối loạn tâm thần (DSM-IV) với một số điều chỉnh nhỏ, trong khi CMSC được đánh giá cho chín vùng cơ thể khác nhau. CWMSC được định nghĩa theo tiêu chí năm 1990 của Đại học thấp khớp Hoa Kỳ. Chúng tôi đã sử dụng hồi quy Poisson để ước tính tỷ lệ nguy cơ đã điều chỉnh (RRs) cho CMSC và CWMSC ở thời điểm theo dõi 11 năm. Độ chính xác của các ước lượng được đánh giá bằng khoảng tin cậy 95% (CIs). Mất ngủ tại điểm khởi đầu có liên quan đến nguy cơ tăng của bất kỳ CMSC nào (RR 1.16, 95% CI 1.03–1.32) và CWMSC (RR 1.58, 95% CI 1.26–1.98) tại thời điểm theo dõi. RR cho CMSC cho các vùng cơ thể cụ thể dao động từ 1.34 (95% CI 1.05–1.73) cho đầu gối và 1.34 (1.10–1.63) cho cổ đến 1.60 (95% CI 1.19–2.14) cho mắt cá/chân. Hơn nữa, mất ngủ có liên quan đến nguy cơ tăng của CMSC ở 3–4 vùng (RR 1.36, 95% CI 1.05–1.77), và 5 vùng trở lên (RR 1.93, 95% CI 1.40–2.66), nhưng không phải ở 1–2 vùng (RR 0.99, 95% CI 0.80–1.24). Mất ngủ có liên quan đến nguy cơ tăng của CMSC, CWMSC, và CMSC phân bố ở 3 vùng cơ thể trở lên.

Từ khóa

#Mất ngủ; vấn đề cơ xương khớp mãn tính; nghiên cứu dọc; HUNT study

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