Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies

Journal of Leukocyte Biology - Tập 70 Số 2 - Trang 185-191 - 2001
Binghe Wang1, Claudio Feliciani2, Irwin Freed1, Qinchao Cai1, Daniel N. Sauder1
1Division of Dermatology, Sunnybrook and Women's College Health Science Centre, University of Toronto , Ontario, Canada M4N 3M5
2Department of Dermatology, University “G.d'Annunzio” , Via dei Vestini Chieti, Italy

Tóm tắt

AbstractContact hypersensitivity (CHS), a dendritic-cell (DC)-dependent, T-cell-mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not fully understood. During the past few years, varieties of gene-targeted knockout mice have been used in the study of CHS. Such studies have contributed significantly to our understanding of the mechanisms responsible for the initiation of CHS. This review focuses on insights into molecular requirements for CHS gained from knockout studies.

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