Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease

Mediators of Inflammation - Tập 2018 - Trang 1-12 - 2018
José L. Reyes1, Danielle T. Vannan2,3, Bertus Eksteen2, Imelda Juárez‐Avelar4, Tonathiu Rodríguez4, Marisol I. González1, Alicia Vázquez-Mendoza5
1Universidad Nacional Autónoma de México (UNAM), Laboratorio de Inmunología experimental y Regulación de la inflamación Hepato-Intestinal, UBIMED, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, Mexico
2Aspen Woods Clinic, Calgary, AB, Canada
3University of Calgary, Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary, AB, Canada
4Universidad Nacional Autónoma de México (UNAM), Unidad de Biomedicina (UBIMED), Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, Mexico
5Universidad Nacional Autónoma de México (UNAM), Laboratorio de Enfermedades Inflamatorias Oculares, Carrera de Optometría, Facultad de Estudios Superiores (FES) Iztacala, Tlalnepantla, MEX, Mexico

Tóm tắt

Dry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality. In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies. The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes. This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED.

Từ khóa


Tài liệu tham khảo

10.1186/1471-2415-12-22

10.1016/j.ajo.2006.11.060

10.1016/j.ajo.2008.08.032

10.1016/S1542-0124(12)70081-2

10.2147/OPTH.S136203

10.1016/j.ajo.2017.05.009

2016, Romanian Journal of Morphology and Embryology, 57, 197

10.1136/bjo.2009.161059

2010, Molecular Vision, 16, 2457

10.4049/jimmunol.1102415

10.1097/MD.0000000000004268

10.1001/archopht.1983.01040010557003

10.1097/ICO.0b013e318030d259

10.1016/S0181-5512(04)96241-9

2002, Investigative Ophthalmology & Visual Science, 43, 2609

10.1097/00003226-199811000-00002

10.1016/j.ajo.2011.08.023

10.1016/j.jtos.2017.05.011

10.1016/j.pharmthera.2017.10.019

10.4317/jced.53605

2001, Journal of Leukocyte Biology, 70, 881, 10.1189/jlb.70.6.881

10.1038/cdd.2011.1

10.1038/cr.2010.150

10.1167/iovs.12-10430

10.1167/iovs.14-15332

10.1016/j.jtos.2015.11.006

10.4049/jimmunol.1500610

10.1371/journal.pone.0125501

10.1016/j.actbio.2011.11.031

10.1038/ni.2419

10.12703/p6-13

10.1002/art.23073

10.1111/iep.12061

10.1007/s00005-015-0335-0

10.1016/j.ajpath.2014.09.006

10.4049/jimmunol.1101442

10.1016/j.ajpath.2012.05.014

10.1111/cei.12378

10.1155/2017/4137563

10.1002/1521-4141(2002010)32:10<2881::AID-IMMU2881>3.0.CO;2-K

10.1038/nm.4023

10.1161/CIRCRESAHA.116.304734

10.1002/hep.28155

10.3389/fmicb.2017.01196

10.1073/pnas.1705491114

10.1089/gtmb.2011.0355

10.1189/jlb.1110611

10.1371/journal.pone.0036822

10.1167/iovs.09-3425

10.1038/srep45312

10.4049/jimmunol.176.7.3950

10.4049/jimmunol.177.1.566

10.4049/jimmunol.171.11.6173

10.1167/iovs.07-1390

10.1038/mi.2009.5

10.1167/iovs.12-11216

10.1371/journal.pone.0078508

10.1167/iovs.16-20789

10.4049/jimmunol.1502641

10.1167/iovs.07-0691

10.1038/nrrheum.2018.1

10.1038/cti.2016.2

10.1016/j.autrev.2011.07.001

10.1016/j.exer.2010.07.008

10.1167/iovs.11-9299

10.1016/j.ajpath.2013.11.019

10.1016/S0091-6749(96)70207-5

10.1038/srep17569

10.1016/j.iac.2007.12.006

10.1167/iovs.08-3365

10.1167/iovs.15-16900

10.1006/exer.1996.0280

10.2332/allergolint.09-OA-0092

10.1002/iid3.189

10.1016/j.cmi.2016.04.008

2016, The Yale Journal of Biology and Medicine, 89, 325

10.3748/wjg.v20.i40.14805

Thông tin
Thông tin xuất bản

Mediators of Inflammation

Tập 2018

1-12

Thông tin tác giả