Các chất ức chế kinaza phụ thuộc cyclin G1 ở động vật có vú.
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#kinaza phụ thuộc cyclin #G1 #chất ức chế CDK #chu kỳ tế bào động vật có vú #điều trị ung thưTài liệu tham khảo
1993, Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes., J. Biol. Chem., 268, 4113, 10.1016/S0021-9258(18)53587-0
1994, CDK6 (PLSTIRE) and CDK4 (PSKJ3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1., Oncogene, 9, 71
1994, Absence of cyclin D/cdk4 complexes in cells lacking functional retinoblastoma protein., Oncogene, 9, 1633
1995, Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kipl, to regions involved in human cancer., Cancer Res., 55, 1199
1994, Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma., Nature Genet., 8, 27, 10.1038/ng0994-27
1995, Identification of human/mouse p19, a novel cdk4/cdk6 inhibitor with homology to p16ink4., Mol. Cell. Biol., 15, 2682, 10.1128/MCB.15.5.2682
1990, Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types., Oncogene, 5, 1731
1994, WAF1/Cip1 is induced in p53-mediated G1 arrest and apoptosis., Cancer Res., 54, 1169
1994, Inactivation of a cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes., Mol. Cell. Biol., 14, 4889
1993, Speculations on the roles of RBI in tissue-specific differentiation, tumor initiation, and tumor progression., FASEB J., 7, 846, 10.1096/fasebj.7.10.8344484
1994, Candidate tumor suppressor MTS1 (p16INK4A) and MTS2 (pl5INK4B) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphoblastic leukemias., Blood, 84, 4038, 10.1182/blood.V84.12.4038.bloodjournal84124038
1995, Novel INK4 proteins, p19 and p18, are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6., Mol. Cell. Biol., 15, 2672, 10.1128/MCB.15.5.2672
1994, The transcription factor, the cdk, its cyclin and their regulator: Directing the transcriptional response to a nutritional signal., EMBO J., 13, 5410, 10.1002/j.1460-2075.1994.tb06876.x
1994, Deletion of p16 and p15 genes in brain tumors., Cancer Res., 24, 6353
1994, Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53., Oncogene, 9, 3397
1991, Participation of p53 protein in the cellular response to DNA damage., Cancer Res., 51, 6304
1994, Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21., Oncogene, 9, 2261
1993, Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents., Blood, 82, 1092, 10.1182/blood.V82.4.1092.1092
1995, Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity., Mol. Cell. Biol., 15, 2600, 10.1128/MCB.15.5.2600
Lukas, J., Parry, D. Aagaard, L. Mann, D.J. Bartkova, J. Strauss, M. Peters, G. and Bartek. J. 1995b. Retinoblastoma protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (in press).
Luo, Y., Hurwitz, J. and Massagué. J. 1995. Cell cycle inhibition mediated by functionally independent CDK and PCNA inhibitory domains in p21CIP1. Nature (in press).
1994, Activation of cyclin-dependent kinase-4 (CDK4) by mouse M015-associated kinase., Mol. Cell. Biol., 14, 7265
1994, D-type cyclin-dependent kinase activity in mammalian cells., Mol. Cell. Biol., 14, 2066
Medema, R., Herrera, R.E. Lam, F. and Weinberg. R.A. 1995. Growth suppression by p16INK4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. (in press).
1994, Identification of a G1 kinase activity for cdk6, a novel cyclin D partner., Mol. Cell. Biol., 14, 2077
1994, Inhibition of WAF1/CIP1 by a p53-independent pathway., Cancer Res., 54, 3391
1994, Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases cdk4 and cdk42 in human T cells., J. Biol. Chem., 52, 32972
1994, Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma., Cancer Res., 54, 3396
1995, Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1., EMBO J., 14, 555, 10.1002/j.1460-2075.1995.tb07031.x
1995, Human cyclin E, a nuclear protein essential for the G1 to S phase transition., Mol. Cell. Biol., 15, 2612, 10.1128/MCB.15.5.2612
1995, Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia., Blood, 85, 2321, 10.1182/blood.V85.9.2321.bloodjournal8592321
1994, Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB., Oncogene, 9, 3375
1995, Lack of cyclin D-cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product., EMBO J., 14, 503, 10.1002/j.1460-2075.1995.tb07026.x
1995, Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias., Cancer Res., 55, 1206
1995, p27Kip1 chromosomal mapping to 12p12 and absence of mutations in human tumors., Cancer Res., 55, 1211
Ranade, K., Hussassian, C.J. Sikorski, R.S. Varmus, H.E. Goldstein, A.M. Tucker, M.A. Serrano, M. Hannon, G.J. Beach, D. and Dracopoli. N.C. 1995. Mutations associated with familial melanoma impair p16INK4 function. Nature Genet. (in press).
1994, Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic-loop-helix regulators., Mol. Cell. Biol., 14, 5259
Resnitzky, D. and Reed. S. 1995. Different roles for cyclins D1 and E in regulation of the G1 to S transition. Mol. Cell. Biol. (in press).
1994, CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas., Cancer Res., 54, 6321
1994, Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: Role of p53-dependent and independent signal transduction pathways., Oncogene, 9, 3407
1994, A novel inhibitor of cyclin-cdk activity detected in transforming growth factor β-arrested epithelial cells., Mol. Cell. Biol., 14, 3683
1994, Induction of p21(WAF-1/CIP1) during differentiation., Oncogene, 9, 3389
1994, Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16INK4., Cancer Res., 54, 5816
1994, Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: Association with cdk4 is required for cyclin D1 function in G1 progression., Oncogene, 9, 2663
Yang, R., Serrano, M. and Koeffler. P. 1995. Mutational effects of the p16INK4a tumor supressor protein. Cancer Res. (in press).