Inhibition of the Emergence of Ciprofloxacin Resistance in Streptococcus pneumoniae by the Multidrug Efflux Inhibitor Reserpine

Antimicrobial Agents and Chemotherapy - Tập 43 Số 4 - Trang 988-989 - 1999
Penelope N. Markham1
1Influx, Inc., Chicago Technology Park, Chicago, Illinois 60612

Tóm tắt

ABSTRACT

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae . In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae , suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.

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Tài liệu tham khảo

10.1128/jb.177.14.3904-3910.1995

10.1128/AAC.41.6.1396

10.1074/jbc.270.44.26092

10.1093/jac/40.3.458

10.1128/AAC.42.8.2032

10.1128/AAC.39.12.2650

10.1128/AAC.40.11.2673

10.1128/AAC.40.10.2252

National Committee for Clinical Laboratory Standards Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 4th ed. Approved standard M7-A4. 1997 National Committee for Clinical Laboratory Standards Villanova Pa

10.1073/pnas.88.11.4781

Takiff H. E. Cinuino M. Musso M. C. Weisbrod T. Martinez R. Salazar L. Bloom B. R. Jacobs W. R. Efflux pumps of the proton antiporter family confer low level fluoroquinolone resistance in Mycobacterium smegmatis. Proc. Natl. Acad. Sci. USA 93 1996 362 366

10.1073/pnas.93.20.10668

10.1128/jb.172.12.6942-6949.1990

10.1128/AAC.41.9.1973