Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

Aghajanian, 1971, Histochemical fluorescence of raphe neurons: selective enhancement by tryptophan, Science, 172, 1159, 10.1126/science.172.3988.1159

Aghajanian, 1974, Pre- and postsynaptic feedback mechanisms in central dopaminergic neurons, 4

Aghajanian, 1973, Use of single unit recording in correlating transmitter turnover with impulse flow in monoamine neurons, 115

Aghajanian, 1968, Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe, Science, 161, 706, 10.1126/science.161.3842.706

Aghajanian, 1974, l-Tryptophan as a selective histochemical marker for serotonergic neurons in single-cell recording studies, Brain Research, 81, 364, 10.1016/0006-8993(74)90954-8

Aghajanian, 1972, Lysergic acid diethylamide and serotonin: direct actions on serotonin containing neurons in rat brain, Life Sci., 11, 615, 10.1016/0024-3205(72)90153-1

Aghajanian, 1967, Serotonin: release in the forebrain by stimulation of midbrain raphe, Science, 156, 402, 10.1126/science.156.3773.402

Andén, 1970, Evidence for a central noradrenaline receptor stimulation by clonidine, Life Sci., 9, 513, 10.1016/0024-3205(70)90207-9

Anderson, 1974, On the mechanism of action of clonidine: effects on single central neurons, Brit. J. Pharmacol., 51, 359, 10.1111/j.1476-5381.1974.tb10670.x

Björklund, 1971, Classification of monoamine neurons in the rat mesencephalon: distribution of a new monoamine neuronal system, Brain Research, 32, 269, 10.1016/0006-8993(71)90324-6

Blondeaux, 1973, Modification du métabolisme de la sérotonine (5-HT) cérébrale induite chez le rat par administration de 6-hydroxydopamine, Brain Research, 50, 101, 10.1016/0006-8993(73)90597-0

Boadle-Biber, 1970, Acceleration of noradrenaline biosynthesis in the guinea-pig vas deferens by potassium, Brit. J. Pharmacol., 40, 702, 10.1111/j.1476-5381.1970.tb10648.x

Bogdanski, 1956, Identification and assay of serotonin in brain, J. Pharmacol. exp. Ther., 117, 82

Boissier, 1968, Cardiovascular effects of 2-(2,6-dichlorophenylamine)-2-imidazole (St 155), Europ. J. Pharmacol., 2, 333, 10.1016/0014-2999(68)90183-0

Bolme, 1971, Pharmacological studies on the hypotensive effects of clonidine, Europ. J. Pharmacol., 13, 168, 10.1016/0014-2999(71)90147-6

Bousquet, 1973, Localization of the central cardiovascular action of clonidine, Brit. J. Pharmacol., 49, 573, 10.1111/j.1476-5381.1973.tb08532.x

Braekkamp, 1972, Clonidine induced intrahypothalamic stimulation of eating in rats, Psychopharmacologia (Berl.), 25, 162, 10.1007/BF00423193

Braestrup, 1974, Effects of phenoxybenzamine, aceperone and clonidine on the level of 3-methoxy-4-hydroxyphenylglycol (MOPEG) in rat brain, J. Pharm. Pharmacol., 26, 139, 10.1111/j.2042-7158.1974.tb09242.x

Bunney, 1973, Electrophysiological effects of amphetamine on dopaminergic neurons, 957

Bunney, 1973, Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity, J. Pharmacol. exp. Ther., 185, 560

Carlsson, 1962, Biochemical and histochemical studies on the effects of imipramine-like drugs and (+) amphetamine on central and peripheral catecholamine neurons, Acta physiol. scand., 55, 95, 10.1111/j.1748-1716.1962.tb02422.x

Carlsson, 1972, Regulation of monoamine metabolism in the central nervous system, Pharmacol. Rev., 24, 371

Carr, 1970, Effects of amphetamine on the contents of norepinephrine and its metabolites in the effluent of perfused cerebral ventricles in the cat, Biochem. Pharmacol., 19, 2361, 10.1016/0006-2952(70)90135-8

Chase, 1967, Serotonin release from brain slices by electrical stimulation: regional differences and effect on LSD, Science, 157, 1461, 10.1126/science.157.3795.1461

Constantine, J. W., and McShane, W. K., Analysis of the cardiovascular effects of 2-(2,6-dichlorophenylamine)-2-imidazoline hydrochloride (Catapresan), Europ. J. Pharmacol., 4 (198) 109–123.

Couch, 1970, Responses of neurons in the raphe nuclei to serotonin, norepinephrine and acetylcholine and their correlation with an excitatory synaptic input, Brain Research, 19, 137, 10.1016/0006-8993(70)90243-X

Dahlström, 1965, Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons, Acta physiol. scand., 62, 1

Dollery, 1973, Central noradrenergic neurons and the cardiovascular actions of clonidine in the rabbit, Brit. J. Pharmacol., 47, 206, 10.1111/j.1476-5381.1973.tb08318.x

Falck, 1962, Fluorescence of catecholamines and related compounds condensed with formaldehyde, J. Histochem. Cytochem., 10, 348, 10.1177/10.3.348

Farnebo, 1971, Drug-induced changes in the release of 3H-monoamines from field stimulated rat brain slices, Acta physiol. scand., 35, 10.1111/j.1748-1716.1971.tb05213.x

Ferris, 1972, J. Pharmacol. exp. Ther., 181, 407

Foote, 1969, Comparison of effects of LSD and amphetamine on midbrain raphe units, Nature (Lond.), 222, 567, 10.1038/222567a0

Fuxe, 1965, Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system, Acta physiol. scand., 64, 37

Glowinski, 1966, Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of 3H-norepinephrine and 3H-dopamine, J. Pharmacol. exp. Ther., 153, 30

Graham, 1971, Effects of amphetamine on single cell activity in a catecholamine nucleus, the locus coeruleus, Nature (Lond.), 234, 100, 10.1038/234100b0

Haeusler, 1973, Activition of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of clonidine, Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak., 278, 231, 10.1007/BF00500285

Haggendal, 1970, Some further aspects on the release of the adrenergic transmitter, 100

Haigler, 1974, Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons containing a serotonergic input, J. Pharmacol. exp. Ther., 188, 688

Harris, 1973, Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex effects of amphetamine analogues, Neuropharmacology, 12, 669, 10.1016/0028-3908(73)90120-2

Hoefke, 1966, Pharmakologische Wirkungen des 2-(2,6-dichlorphenylamino)-2-imidazolin-hydrochloride, einer neuen, antihypertensiven Substanz, Arzneimittel-Forsch., 16, 1038

Hökfelt, 1974, Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain, Brain Research, 66, 235, 10.1016/0006-8993(74)90143-7

Holman, 1971, Sleep produced by clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride), Brit. J. Pharmacol., 43, 685, 10.1111/j.1476-5381.1971.tb07203.x

Johnson, 1972, 5-Hydroxyindole levels in rat brain after inhibition of dopamine β-hydroxylase, J. Pharmacol. exp. Ther., 180, 539

Jouvet, 1973, Monoaminergic regulation of sleep-waking cycle

Juge, 1972, Modification du métabolisme de la sérotonine (5-HT) cérébrale après 6-hydroxydopamine chez le rat, C. R. Acad. Sci. (Paris), 274, 3266

Katic, 1972, The central action of clonidine and its antagonism, Brit. J. Pharmacol., 44, 779, 10.1111/j.1476-5381.1972.tb07315.x

Kehr, 1972, Evidence for a receptor mediated feedback control of striatal tyrosine hydroxylase activity, J. Pharm. Pharmacol., 24, 744, 10.1111/j.2042-7158.1972.tb09104.x

Klupp, 1970, Effects of clonidine on central sympathetic tone, Europ. J. Pharmacol., 10, 225, 10.1016/0014-2999(70)90276-1

Kobinger, 1974, Evidence for direct α-adrenoceptor stimulation of effector neurons in cardiovascular centers by clonidine, Europ. J. Pharmacol., 27, 151, 10.1016/0014-2999(74)90214-3

Kobinger, 1967, Investigations into the mechanisms of the hypotensive effect of 2-(2,6-dichlorophenylamino)-2-imidazoline · HCl, Europ. J. Pharmacol., 2, 155, 10.1016/0014-2999(67)90080-5

Kobinger, 1972, Facilitation of vagal reflex bradycardia by an action of clonidine on central α-receptors, Europ. J. Pharmacol., 19, 210, 10.1016/0014-2999(72)90011-8

König, 1970, The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem, 162

Korf, 1973, Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulphate levels in the rat cerebral cortex, Europ. J. Pharmacol., 21, 305, 10.1016/0014-2999(73)90131-3

Korf, 1974, Noradrenergic neurons: morphine inhibition of spontaneous activity, Europ. J. Pharmacol., 25, 165, 10.1016/0014-2999(74)90045-4

Kostowski, 1969, Electrical stimulation of midbrain raphe: biochemical, behavioral and bioelectrical effects, Europ. J. Pharmacol., 7, 170, 10.1016/0014-2999(69)90006-5

Langer, 1973, The regulation of transmitter release elicited by nerve stimulation through a presynaptic feedback mechanism, 543

Loizou, 1969, Projections of the nucleus locus coeruleus in the albino rat, Brain Research, 15, 563, 10.1016/0006-8993(69)90185-1

Maj, 1973, Effect of clonidine on the 5-hydroxytryptamine and 5-hydroxyindoleacetic acid brain levels, Biochem. Pharmacol., 22, 2679, 10.1016/0006-2952(73)90128-7

McClean, 1961, Effect of d-amphetamine on rat brain noradrenaline and serotonin, 107, 77

Moore, 1963, Effects of d-amphetamine and restraint on the content of norepinephrine and dopamine in rat brain, Biochem. Pharmacol., 12, 1283, 10.1016/0006-2952(63)90196-5

Morgane, 1974, Inhibition of unit activity in the anterior raphe by stimulation of the locus coeruleus, Anat. Rec., 178, 241

Ng, 1970, Drug-induced release of 3H-norepinephrine and 3H-serotonin from brain slices, Nature (Lond.), 228, 468, 10.1038/228468a0

Rochette, 1974, Influence de la clonidine et la liberation de la noradrénaline dans différentes structures cérébrales du rat, J. Pharmacol. (Paris), 5, 209

Roth, 1968, The action of reserpine on noradrenaline biosynthesis in sympathetic nerve tissue, Biochem. Pharmacol., 17, 1581, 10.1016/0006-2952(68)90218-9

Salmoiraghi, 1967, Micromethods in neuropharmacology: an approach to the study of anesthetics, Anesthesiology, 28, 54, 10.1097/00000542-196701000-00007

Sanan, 1962, Effects of drugs on the noradrenaline content of brain and peripheral tissues and its significance, Brit. J. Pharmacol., 18, 108

Sattler, 1967, Acute hypotensive action of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155) after infusion into the cat's vertebral artery, Europ. J. Pharmacol., 2, 9, 10.1016/0014-2999(67)90016-7

Scheel-Krüger, 1974, Studies of various amphetamines, apomorphine and clonidine on body temperature and brain 5-hydroxytryptamine metabolism in rats, Psychopharmacologia (Berl.), 36, 189, 10.1007/BF00421801

Schmitt, 1970, Interactions between 2-(2,6-dichlorophenylamino)-2-imidazole hydrochloride (St 155, Catepresan) and α-adrenergic blocking drugs, Europ. J. Pharmacol., 9, 9, 10.1016/0014-2999(70)90313-4

Schmitt, 1971, Evidence for an α-sympathomimetic component in the effects of Catapresan on vasomotor centers: antagonism by piperoxane, Europ. J. Pharmacol., 14, 98, 10.1016/0014-2999(71)90130-0

Shaw, 1971, Sites of central nervous system action of clonidine on reflex autonomic function in the unanesthetized rabbit, Europ. J. Pharmacol., 15, 66, 10.1016/0014-2999(71)90080-X

Sheard, 1968, Stimulation of the midbrain raphe: effect on serotonin metabolism, J. Pharmacol. exp. Ther., 163, 425

Sherman, 1968, Evidence for a central hypotensive mechanism of 2-(2,6-dichlorophenylamino)-3-imidazoline (Catepresan, St 155), Europ. J. Pharmacol., 2, 326, 10.1016/0014-2999(68)90087-3

Starke, 1973, Regulation of catecholamine release: receptor mediated feedback control in peripheral and central neurones, 561

Starke, 1973, Inhibition of adrenergic neurotransmission by clonidine: an action on prejunctional α-receptors, Neuropharmacology, 12, 339, 10.1016/0028-3908(73)90093-2

Starke, 1973, Involvement of α-receptors in clonidine induced inhibition of transmitter release from central monoamine neurons, Neuropharmacology, 12, 1073, 10.1016/0028-3908(73)90051-8

Starke, 1972, Adrenergic neuron blockade by clonidine: comparison with guanethidine and local anesthetics, Arch. int. Pharmacodyn., 195, 291

Stein, 1974, Effects of α-methyl-p-tyrosine upon cerebral amine metabolism and sleep states in the cat, Brain Research, 72, 360, 10.1016/0006-8993(74)90882-8

Stein, 1960, Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine, J. comp. physiol. Psychol, 67, 189, 10.1037/h0026767

Svensson, 1971, Functional and biochemical effects of d- and l-amphetamine on central catecholamine neurons, Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak., 271, 170, 10.1007/BF00998578

Tasaki, 1968, A simple, direct and rapid method for filling microelectrodes, Physiol. Behav., 3, 1009, 10.1016/0031-9384(68)90193-5

Thomas, 1965, Precise localization of Renshaw cells with a new marking technique, Nature (Lond.), 206, 211, 10.1038/206211b0

Thornburg, 1973, Dopamine and norepinephrine uptake by rat brain synaptosomes: relative inhibitory potencies of l- and d-amphetamine and amantadine, Res. Commun. Chem. Path. Pharmacol., 5, 81

Tilson, 1972, Studies on the concurrent behavioral and neurochemical effects of psychoactive drugs using the push-pull cannula, J. Pharmacol. exp. Ther., 181, 387

Tsoucaris-Kupfer, 1972, Hypothermic effect of α-sympathomimetic agents and their antagonism by adrenergic and cholinergic blocking drugs, Neuropharmacology, 11, 625, 10.1016/0028-3908(72)90071-8

Ungerstedt, 1971, Stereotaxic mapping of the monoamine pathways in the rat brain, Acta physiol. scand., 267, 1, 10.1111/j.1365-201X.1971.tb10998.x

Ungerstedt, 1971, Histochemical studies on the effect of intracerebral and intraventricular injections of 6-hydroxydopamine on monoamine neurons in the rat brain, 101

VanSpanning, 1973, The interference of tricyclic antidepressants with the central hypotensive effect of clonidine, Europ. J. Pharmacol., 24, 402, 10.1016/0014-2999(73)90169-6

Walter, 1973, Increase of noradrenaline metabolism following electrical stimulation of the locus coerulues in the rat, J. Neurochem., 21, 281, 10.1111/j.1471-4159.1973.tb04249.x

Walters, 1974, Locus coeruleus neurons: inhibition of firing by d- and l-amphetamine, 33, 294

Ziance, 1972, Characteristics of amphetamine-induced release of norepinephrine from rat cerebral cortex in vitro, J. Pharmacol. exp. Ther., 182, 284