Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate

Nature Communications - Tập 6 Số 1
Kiriko Hiraoka1, Takahiro Inoue1, Rhys Dylan Taylor2, Takayoshi Watanabe1, Nobuko Koshikawa1, Hiroyuki Yoda1, Ken‐ichi Shinohara1, Atsushi Takatori1, Hirokazu Sugimoto3, Yoshiaki Maru1, Tadamichi Denda4, Kyoko Fujiwara5, Allan Balmain6, Toshinori Ozaki3, Toshikazu Bando2, Hiroshi Sugiyama2, Hiroki Nagase1
1Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.
2Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan
3Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.
4Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan.
5Innovative Therapy Research Group, Nihon University Research Institute of Medical Science, Nihon University School of Medicine, 30-1 Ooyaguchi-kami, Itabashi-ku, Tokyo 173-8610, Japan.
6Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA.

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