Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate
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Perez, R. et al. A view on EGFR-targeted therapies from the oncogene-addiction perspective. Front. Pharmacol. 4, 53 (2013).
Rokita, M. et al. Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system. Onco. Targets Ther. 6, 967 (2013).
Neumann, J. et al. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol. Res. Pract. 205, 858 (2009).
The American Cancer Society. American Cancer Society. Cancer Facts & Figures 2013 American Cancer Society (2013).
Zimmermann, G. et al. Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling. Nature 497, 631 (2013).
Ostrem, J. M. et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548 (2013).
Shima, F. et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc. Natl Acad. Sci. USA 110, 8182 (2013).
Matsuda, H. et al. Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-beta1 promoter. Kidney Int. 79, 46 (2011).
Wang, X. et al. Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide. Cancer Sci. 101, 759 (2010).
Yang, F. et al. Antitumor activity of a pyrrole-imidazole polyamide. Proc. Natl Acad. Sci. USA 110, 1863 (2013).
Bando, T. & Sugiyama, H. Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides. Acc. Chem. Res. 39, 935 (2006).
Wang, Y. D. et al. Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate. J. Biol. Chem. 277, 42431–42437 (2002).
Wurtz, N. R. & Dervan., P. B. Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates. Chem. Biol. 7, 153–161 (2000).
Taylor, R. D. et al. Sequence-Specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates. Eur. J. Chem. 20, 1310 (2014).
Collado, M. & Serrano, M. Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer 10, 51 (2010).
Liu, Y. & Bodmer, W. F. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc. Natl Acad. Sci. USA 103, 976 (2006).
Tortolina, L. et al. A multi-scale approach to colorectal cancer: from a biochemical-interaction signaling-network level, to multi-cellular dynamics of malignant transformation. Interplay with mutations and onco-protein inhibitor drugs. Curr. Cancer Drug Targets 12, 339 (2012).
Bando, T. et al. Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: sequence-specific alkylation with nine-base-pair recognition. Bioconjug. Chem. 17, 715 (2006).
Dickinson, L. A. et al. Arresting cancer proliferation by small-molecule gene regulation. Chem. Biol. 11, 1583–1594 (2004).
Jespersen, C. et al. Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg. Med. Chem. Lett. 12, 4068–4071 (2012).
Lengauer, C. et al. Cancer drug discovery through collaboration. Nat. Rev. Drug Discov. 4, 375–380 (2005).
Raskatov, J. A. et al. Tumor xenograft uptake of a pyrrole-imidazole (py-im) polyamide varies as a function of cell line grafted. J. Med. Chem. 57, 8471–8476 (2014).