Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Molecular and Cellular Biology - Tập 25 Số 9 - Trang 3553-3562 - 2005
Randi G. Syljuåsen1, Claus Storgaard Sørensen2,3, Lasse Tengbjerg Hansen4, Kasper Fugger2, Cecilia Lundin5, Fredrik J. Swartling5, Thomas Helleday5,6, Maxwell Sehested7, Jiří Lukáš2, Jiří Bártek2
1Institute of Cancer Biology, Department of Cell Cycle and Cancer, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark.
2Institute of Cancer Biology, Danish Cancer Society
3University of Copenhagen
4Institute of Molecular Pathology, University of Copenhagen
5Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
6The Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom
7Department of Pathology, Rigshospitalet 5444, Copenhagen, Denmark

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