Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo‐controlled double‐blind trial

Psycho-Oncology - Tập 21 Số 3 - Trang 247-254 - 2012
Deborah H. Ndao1, Elena J. Ladas1, Bin Cheng2, Stephen Sands1, Kathryn Snyder3, James H. Garvin1, Kara M. Kelly1
1Division of Pediatric Oncology, Columbia University Medical Center, New York, NY, USA
2Department of Biostatistics, Columbia University Medical Center, Mailman School of Public Health, New York, NY, USA
3Department of Pediatrics, Columbia University Medical Center, Cornell University Medical Center, New York Presbyterian Hospital, New York, NY, USA

Tóm tắt

AbstractObjective: Though often lifesaving, stem cell transplantation (SCT) is a period of great distress for both child and parent.Methods: We conducted a double‐blind, placebo‐controlled randomized study evaluating the effect of the respiratory administration of bergamot essential oil on the anxiety, nausea, and pain of 37 pediatric patients with malignant and non‐malignant disorders undergoing stem cell infusion and their parents. Patients were assessed at the time of recruitment, prior to infusion, upon infusion completion, and one hour post‐infusion using the Spielberger State‐Trait Anxiety Inventory (STAI) for parents and the STAIC, Children's Behavioral Style Scale (CBSS), visual analogue scale (VAS) for pain and nausea, and the Emotionality Activity Sociability and Impulsivity instrument (EASI) for children.Results: Children and adolescents in the treatment group experienced greater anxiety (p = 0.05) and nausea (p = 0.03) one hour post‐infusion. Reported pain in both groups was no longer significant one hour post‐infusion. Parental anxiety declined in both groups but did not reach statistical significance. Child's monitoring coping style was significantly predictive of transitory anxiety post‐infusion (p = 0.01).Conclusions: Although this trial did not report a benefit of inhalation aromatherapy for reducing anxiety, nausea, or pain when added to standard supportive care, it provides the first experimental rather than descriptive report on testing a single therapeutic essential oil among children and adolescents undergoing stem cell infusion. Future research may consider exploring the cutaneous application of essential oil through massage or other psychoeducational counseling interventions among parents with elevated anxiety and patients with greater information seeking coping styles during SCT. Copyright © 2010 John Wiley & Sons, Ltd.

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Tài liệu tham khảo

Rodrigue JR, 1995, Behavioral distress, fear, and pain among children hospitalized for bone marrow transplantation, Clin Transplant, 9, 454

10.1038/sj.bmt.1701853

10.1542/peds.113.6.1700

Zambelli A, 1998, Clinical toxicity of cryopreserved circulating progenitor cells infusion, Anticancer Res, 18, 4705

10.1097/00002820-200004000-00010

10.1046/j.1537-2995.1993.33793325053.x

10.1038/sj.bmt.1705417

10.1037/0278-6133.14.3.236

10.1016/S0952-8180(00)00214-2

10.1016/S0959-8049(97)00176-7

10.1097/00043426-200009000-00005

10.1089/acm.2006.12.291

National Cancer Institute U.S. National Institutes of Health. Aromatherapy and essential oils (PDQ®). Available from:http://www.cancer.gov/cancertopics/pdq/cam/aromatherapy/HealthProfessional. Accessed on 29 April2010.

10.1177/146642409711700511

10.1200/JCO.2003.10.126

Cooke B, 2000, Aromatherapy: a systematic review, Br J Gen Pract, 50, 493

Wildwood C, 1996, The Encyclopedia of Aromatherapy

Price S, 1996, Aromatherapy for Babies and Children

10.1093/jpepsy/20.2.217

Buss AH, 1984, Temperament: Early Developing Personality Traits

Speilberger CD, 1973, State‐Trait Anxiety Inventory for Children

Speilberger CD, 1983, State‐Trait Anxiety Inventory for Adults

Weibe E, 2000, A randomized trial of aromatherapy to reduce anxiety before abortion, Eff Clin Pract, 3, 166

10.1016/j.explore.2007.04.009

10.1111/j.1600-0528.2009.00511.x

10.1046/j.1365-2648.1997.t01-15-00999.x

10.1016/j.pnpbp.2010.02.020

Rombola L, 2009, Effects of systematic administration of essential oil of bergamot (BEO) on gross behavior and EEG power spectra recorded from the rat hippocampus and cerebral cortex, Funct Neurol, 24, 107

10.1016/j.phymed.2009.10.002

10.1046/j.1365-2702.1999.00250.x

10.1016/j.fitote.2010.01.013

10.1002/ptr.2072

10.1200/JCO.2006.08.9987

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Psycho-Oncology

Tập 21 Số 3

247-254

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