Influence of epidural dexamethasone on maternal temperature and serum cytokine concentration after labor epidural analgesia

International Journal of Gynecology & Obstetrics - Tập 113 - Trang 40-43 - 2011
Li-Zhong Wang1, Xiao-Xia Hu1, Xia Liu2, Ping Qian3, Jia-Mei Ge2, Bei-Lei Tang1
1Department of Anesthesiology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China
2Department of Obstetrics, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China
3Department of Pathology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China

Tóm tắt

AbstractObjectiveTo evaluate the effects of epidural dexamethasone on maternal temperature and serum cytokine levels after labor epidural analgesia.MethodsSixty healthy term nulliparas in spontaneous labor were randomized to receive epidural analgesia alone using bupivacaine 0.125% and fentanyl 1 μg/mL (group I) or epidural analgesia combined with dexamethasone 0.2 mg/mL (group II) (n = 30 per group). Maternal tympanic temperature was measured before epidural analgesia and hourly thereafter until delivery. Maternal and cord venous blood were sampled for analysis of interleukin‐6 (IL‐6), tumor necrosis factor‐α, and interleukin‐10 levels.ResultsThere was no difference in the incidence of intrapartum fever (38 °C or more) between the 2 groups (3/30 versus 1/30, P = 0.612). The mean maternal temperature increased with time in group I, with the elevation reaching statistical significance at 4 hours post analgesia and at delivery compared with baseline (P = 0.012 and P = 0.043, respectively). A similar trend was observed with maternal serum IL‐6 levels in group I. In group II, maternal temperature and IL‐6 levels did not differ from baseline at any time point during labor.ConclusionEpidural dexamethasone alleviates maternal temperature elevation after epidural analgesia. This effect can be attributed to the decrease in IL‐6 levels.

Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

International Journal of Gynecology & Obstetrics

Tập 113

40-43

Thông tin tác giả