Influence of Genetic Interactions on Polygenic Prediction

G3: Genes, Genomes, Genetics - Tập 10 Số 1 - Trang 109-115 - 2020
Zhijun Dai1, Norton E. Long2, Wen Huang1
1Department of Animal Science, and
2Institute for Cyber-Enabled Research, Michigan State University, East Lansing, MI 48824

Tóm tắt

Abstract Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it’s now possible to account for the majority of genetic variation through model fitting, prediction of phenotypes remains a challenge, especially across populations that have diverged in the past. In this study, we designed simulation experiments to specifically investigate the role of genetic interactions in failure of polygenic prediction. We found that non-additive genetic interactions can significantly reduce the accuracy of polygenic prediction. Our study demonstrated the importance of considering genetic interactions in genetic prediction.

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