Inflammatory Marker but Not Adipokine Predicts Mortality among Long-Term Hemodialysis Patients

Mediators of Inflammation - Tập 2007 - Trang 1-5 - 2007
Yu‐Che Tsai1, Chien‐Te Lee1, Tiao‐Lai Huang2, Ben‐Chung Cheng1, Chien-Chun Kuo3, Yih Su3, Hwee‐Yeong Ng1, Chih-Chau Yang1, Fong-Rong Chuang1, Shang‐Chih Liao1
1Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung Hsien 833
2Department of Psychiatry, Chang-Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung Hsien 833
3Department of International Trade, Cheng Shiu University, Kaohsiung Hsien 833

Tóm tắt

Aims: chronic inflammation contributes significantly to the morbidity and mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and clinical features can predict the outcome of hemodialysis patients.Materials and methods: we enrolled 181 hemodialysis patients (men: 97, mean age:56.3±13.6) and analyzed predictors of long-term outcomes.Results: during the 3-year followup period, 41 patients died; the main causes of death were infection and cardiovascular disease. Elevated serum levels of hsCRP and albumin and advanced age were highly associated with death (allP<.001). Leptin and adiponectin levels were not significantly different between deceased patients and survivors. Cox-regression analysis indicated that age, diabetes, albumin level, and hsCRP were independent factors predicting mortality.Conclusion: the presence of underlying disease, advanced age, and markers of chronic inflammation is strongly related to survival rate in long-term hemodialysis patients.

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Tài liệu tham khảo

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Mediators of Inflammation

Tập 2007

1-5

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