Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
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Steinman, R.M. The dendritic Cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271–296 (1991).
Young, J.W. & Inaba, K., Dendritic Cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J. Exp. Med. 183, 7–11 (1996).
Siddiqui, J. et al. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc. Natl. Acad. Sci. USA 85, 2320–2323 (1988).
Steinman, R.M. & Witmer, M.D. Lymphoid dendritic Cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75, 5132–5136 (1978).
Van Voorhis, W.C. et al. Relative efficacy of human monocytes and dendritic Cells as accessory Cells for T Cell replication. J. Exp. Med. 158, 174–191 (1983).
Inaba, K., Young, J.W. & Steinman, R.M. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic Cells. J. Exp. Med. 166, 182–194 (1987).
Young, J.W. & Steinman, R.M. Dentritic Cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T Cells. J. Exp. Med. 171, 1315–1332 (1990).
Inaba, K., Metlay, J.P., Crowley, M.T. & Steinman, R.M., Dendritic Cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T Cells in situ. J. Exp. Med. 172, 631–640 (1990).
Liu, L.M. & MacPherson, G.G. Antigen acquisition by dendritic Cells: Intestinal dendritic Cells acquire antigen administered orally and can prime naive T Cells in vivo. J. Exp. Med. 177, 1299–1307 (1993).
Macatonia, S.E., Taylor, P.M., Knight, S.C. & Askonas, B.A. Primary stimulation by dendritic Cells induces antiviral proliferative and cytotoxic T Cell responses in vitro. J. Exp. Med. 169, 1255–1264 (1988).
Mehta-Damani, A., Markowicz, S. & Engleman, E.G. Generation of antigen-specific CD8+ CTLs from naive precursors. J. Immunol. 153, 996–1003 (1994).
Takahashi, H., Nakagawa, Y., Yokomuro, K. & Berzofsky, J.A. Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic Cells. Int. Immunol. 5, 849–857 (1993).
Mayordomo, J.I. et al. Bone marrow-derived dendritic Cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med. 1, 1297–1302 (1995).
Bakkar, A.B.H. et al. Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic Cells in vitro. Cancer Res. 55, 5330–5334 (1995).
Flamand, V. et al. Murine dendritic Cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24, 605–610 (1994).
Guo, Y. et al. Effective tumor vaccine generated by fusion of hepatoma Cells with activated B Cells. Science 263, 518–520 (1994).
Romani, N. et al. Proliferating dendritic Cell progenitors in human blood. J. Exp. Med. 180, 83–93 (1994).
Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic Cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179, 1109–1118 (1994).
Porgador, A. & Gilboa, E. Bone marrow-generated dendritic Cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J. Exp. Med. 182, 255–260 (1995).
Inaba, K. et al. Generation of large numbers of dendritic Cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693–1702 (1992).
Wexler, H. Accurate identification of experimental pulmonary metastases. J. Natl. Cancer Inst. 36, 641–643 (1966).