Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

American Association for the Advancement of Science (AAAS) - Tập 331 Số 6015 - Trang 337-341 - 2011
Koji Atarashi1, Takeshi Tanoue1, Tatsuichiro Shima2, Akemi Imaoka2, Tomomi Kuwahara3, Yoshika Momose4, Genhong Cheng5, Sho Yamasaki6, Takashi Saito6, Yusuke Ohba7, Tadatsugu Taniguchi1, Kiyoshi Takeda8, Shohei Hori9, Ivaylo I. Ivanov10, Yoshinori Umesaki2, Kikuji Itoh4, Kenya Honda1,11
1Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
2Yakult Central Institute for Microbiological Research, Tokyo 186-8650, Japan
3Department of Molecular Bacteriology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.
4Department of Veterinary Public Health, University of Tokyo, Tokyo 113-8657, Japan.
5Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
6Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan
7Laboratory of Pathophysiology and Signal Transduction, Hokkaido University, Graduate School of Medicine, Sapporo 060-8638, Japan.
8Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
9Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan
10Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
11Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan

Tóm tắt

Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice.

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