Mô hình biểu hiện đơn lẻ và đồng biểu hiện của yếu tố tăng trưởng thần kinh và heme oxygenase-1 dự đoán thời gian sống ngắn hơn ở bệnh nhân ung thư dạ dày

Diagnostic Pathology - Tập 12 - Trang 1-12 - 2017
Sang Jae Noh1, Kyoung Min Kim2, Kyu Yun Jang2
1Department of Forensic Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea
2Department of Pathology, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea

Tóm tắt

Yếu tố tăng trưởng thần kinh (NGF) là một yếu tố thần kinh thuộc nhóm neurotrophic có tác dụng điều chỉnh sự phát triển và sự nhân lên của tế bào. Gần đây, có giả thuyết rằng NGF kích thích sự biểu hiện của heme oxygenase-1 (HO1), và cả NGF lẫn HO1 đều tham gia vào quá trình tiến triển của các khối u ác tính ở người. Tuy nhiên, vai trò chính xác của NGF và HO1 trong sinh u vẫn còn gây tranh cãi. Do đó, chúng tôi đã nghiên cứu sự biểu hiện và mối tương quan của NGF và HO1 trong mô ung thư dạ dày của người. Chúng tôi đã kiểm tra sự biểu hiện miễn dịch hóa học của NGF và HO1 trong 167 trường hợp ung thư dạ dày và so sánh với các yếu tố lâm sàng mô học dự đoán khác. Sự biểu hiện của NGF và HO1 là dương tính trong 40% (67/167) và 51% (85/167) các trường hợp, tương ứng, và sự biểu hiện của chúng có mối tương quan đáng kể với nhau (p < 0.001). Các mô hình biểu hiện riêng lẻ của NGF và HO1, cùng với mô hình đồng biểu hiện của hai phân tử này có mối liên hệ đáng kể với thời gian sống ngắn hơn qua phân tích đơn biến. Sự biểu hiện của HO1 (thời gian sống tổng thể; p < 0.001, thời gian sống không tái phát; p = 0.002) và mô hình đồng biểu hiện của NGF và HO1 (thời gian sống tổng thể; p = 0.002, thời gian sống không tái phát; p = 0.003) là những chỉ số dự đoán độc lập kém cho bệnh nhân ung thư dạ dày qua phân tích đa biến. Những kết quả này cho thấy rằng các mô hình biểu hiện đơn lẻ và đồng biểu hiện của NGF và HO1 có thể được sử dụng làm chỉ số dự đoán cho bệnh nhân ung thư dạ dày.

Từ khóa

#yếu tố tăng trưởng thần kinh #heme oxygenase-1 #ung thư dạ dày #chỉ số dự đoán #biểu hiện đồng thể

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