Increased hepatitis C virus (HCV)-specific CD4+CD25 + regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normalversusabnormal alanine aminotransferase levels

Alter, 1997, Hepatitis C in asymptomatic blood donors, Hepatology, 3, S29, 10.1002/hep.510260705

Persico, Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels, Gastroenterology, 200, 760

Jamal, 1999, Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States, Hepatology, 30, 1307, 10.1002/hep.510300526

Chisari, 1997, Cytotoxic T cells and viral hepatitis, J Clin Invest, 99, 1472, 10.1172/JCI119308

Napoli, 1996, Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines, Hepatology, 24, 759, 10.1002/hep.510240402

Quiroga, 1998, Induction of interleukin-12 production in chronic hepatitis C virus infection correlates with the hepatocellular damage, J Infect Dis, 178, 247, 10.1086/517446

Abrignani, 1997, Immune responses throughout hepatitis C virus (HCV) infection: HCV from the immune system point of view, Springer Semin Immunopathol, 19, 47, 10.1007/BF00945024

Rehermann, 2000, Interaction between the hepatitis C virus and the immune system, Semin Liver Dis, 20, 127, 10.1055/s-2000-9946

Khakoo, 1997, Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity, Am J Pathol, 150, 963

Rico, 2002, Features of the CD4+ T-cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels, J Hepatol, 36, 408, 10.1016/S0168-8278(01)00281-1

Baecher-Allan, 2001, CD4+CD25 high regulatory cells in human peripheral blood, J Immunol, 167, 1245, 10.4049/jimmunol.167.3.1245

Jonuleit, 2001, Identification and functional characterization of human CD4(+) CD25(+) T cells with regulatory properties isolated from peripheral blood, J Exp Med, 193, 1285, 10.1084/jem.193.11.1285

Ng, 2001, Human CD4(+) CD25(+) cells: a naturally occurring population of regulatory T cells, Blood, 98, 2736, 10.1182/blood.V98.9.2736

Stephens, 2001, Human CD4(+) CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro, Eur J Immunol, 31, 1247, 10.1002/1521-4141(200104)31:4<1247::AID-IMMU1247>3.0.CO;2-M

Sakaguchi, 2000, Regulatory T cells: key controllers of immunologic self-tolerance, Cell, 101, 455, 10.1016/S0092-8674(00)80856-9

Shevach, 2000, Regulatory T cells in autoimmmunity, Annu Rev Immunol, 18, 423, 10.1146/annurev.immunol.18.1.423

Sakaguchi, 1995, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J Immunol, 155, 1151, 10.4049/jimmunol.155.3.1151

Bluestone, 2003, Natural versus adaptive regulatory T cells, Nat Rev Immunol, 3, 253, 10.1038/nri1032

Woo, 2002, Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation, J Immunol, 168, 4272, 10.4049/jimmunol.168.9.4272

Belkaid, 2002, CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity, Nature, 420, 502, 10.1038/nature01152

Suvas, 2003, CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses, J Exp Med, 198, 889, 10.1084/jem.20030171

Aandahl, 2004, Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens, J Virol, 78, 2454, 10.1128/JVI.78.5.2454-2459.2004

Cabrera, 2004, An immunomodulatory role for CD4(+) CD25(+) regulatory T lymphocytes in hepatitis C virus infection, Hepatology, 40, 1062, 10.1002/hep.20454

Knodell, 1981, Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis, Hepatology, 5, 431, 10.1002/hep.1840010511

Desmet, 1994, Classification of chronic hepatitis: diagnosis, grading and staging, Hepatology, 6, 1513, 10.1002/hep.1840190629

Baecher-Allan, 2001, CD4+CD25high regulatory cells human peripheral blood, J Immunol, 167, 1245, 10.4049/jimmunol.167.3.1245

Waldrop, 1998, Normal human CD4+ memory T cells display broad heterogenicity in their activation threshold for cytokine synthesis, J Immunol, 161, 5284, 10.4049/jimmunol.161.10.5284

Laurel, 2000, Optimization of whole blood antigen-specific cytokine assays for CD4+ T cells, Cytometry, 40, 60, 10.1002/(SICI)1097-0320(20000501)40:1<60::AID-CYTO8>3.0.CO;2-J

Waldrop, 1997, Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency, J Clin Invest, 99, 1739, 10.1172/JCI119338

Barrat, 2002, In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines, J Exp Med, 195, 603, 10.1084/jem.20011629

Chatenoud, 2000, Suppressor T cells they’re back and critical for regulation of autoimmunity, Immunol Rev, 182, 149, 10.1034/j.1600-065X.2001.1820112.x

Khanna, 1997, In vivo hyperexpression of transforming growth factor-beta1 in mice: stimulation by cyclosporine, Transplantation, 63, 1037, 10.1097/00007890-199704150-00026

Valitutti, 1996, Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy, J Exp Med, 183, 1917, 10.1084/jem.183.4.1917

Read, 2000, Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation, J Exp Med, 192, 295, 10.1084/jem.192.2.295

Shimizu, 2002, Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance, Nat Immunol, 3, 135, 10.1038/ni759

Schubert, 2001, Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation, J Biol Chem, 276, 37672, 10.1074/jbc.M104521200

Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490

Levings, 2002, Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells, J Exp Med, 196, 1335, 10.1084/jem.20021139

Groux, 1997, A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature, 389, 737, 10.1038/39614

Weiner, 2001, Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells, Immunol Rev, 182, 207, 10.1034/j.1600-065X.2001.1820117.x

Bain, 2001, Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection, Gastroenterology, 120, 512, 10.1053/gast.2001.21212

Kanto, 1999, Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals, J Immunol, 162, 5584, 10.4049/jimmunol.162.9.5584

Liaw, 1995, T-cell-mediated autologous hepatocytotoxicity in patients with chronic hepatitis C virus infection, Hepatology, 22, 1368

Jin, 1997, The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage, J Clin Immunol, 17, 140, 10.1023/A:1027326415164

Singh, 2001, Control of intestinal inflammation by regulatory T cells, Immunol Rev, 182, 190, 10.1034/j.1600-065X.2001.1820115.x

Hori, 2002, CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice, Eur J Immunol, 32, 1289, 10.1002/1521-4141(200205)32:5<1282::AID-IMMU1282>3.0.CO;2-#

Roths, 1992, Both immunity and hyperresponsiveness to Pneumocystis carinii results from transfer of CD4+, but not CD8+, T cells into severe combined immunodeficiency mice, J Clin Invest, 90, 673, 10.1172/JCI115910