Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis
Tóm tắt
Progestins increase the risk of breast cancer in the hormone therapy of menopause, and progesterone receptor‐induced fatty acid synthase (FAS) is a potential therapeutical target of breast cancer. In a first attempt to specify in which lesions at risk of breast cancer progestins might be acting, we have compared the progesterone receptor (PR) and FAS expression in preinvasive breast lesions and in adjacent “normal” mammary glands. We used archive paraffin‐embedded tissues from 116 patients, with 164 lesions of increasing histological risk from nonproliferative “benign” breast disease (BBD) to
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Tài liệu tham khảo
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