Increased bone formation around coated implants

Journal of Clinical Periodontology - Tập 36 Số 8 - Trang 698-704 - 2009
Bernd Stadlinger1, Susanne Bierbaum2,3, Silke Grimmer1, Matthias C. Schulz1, Eberhard Kuhlisch4, Dieter Scharnweber3, Uwe Eckelt1, Ronald Mai1
1Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Technology Dresden, D-01307 Dresden, Germany
2Biomet Deutschland GmbH, D-14167 Berlin, Germany
3Max-Bergmann-Center of Biomaterials, University of Technology Dresden, D-01062 Dresden, Germany
4Institute for Medical Informatics and Biometry, Faculty of Medicine, University of Technology Dresden, D-01307 Dresden, Germany

Tóm tắt

AbstractAim: We hypothesized that coating threaded, sandblasted acid‐etched titanium implants with collagen and chondroitin sulphate (CS) increases bone formation and implant stability, compared with uncoated controls.Materials and Methods: Three different implant surface conditions were applied: (1) sandblasted acid‐etched (control), (2) collagen/chondroitin sulphate (low‐dose – CS1), (3) collagen/chondroitin sulphate (high‐dose – CS2). Sixty 9.5 mm experimental implants were placed in the mandible of 20 minipigs. Bone–implant contact (BIC) and relative peri‐implant bone‐volume density (rBVD – relation to bone‐volume density of the host bone) were assessed after 1 and 2 months of submerged healing. Implant stability was measured by resonance frequency analysis (RFA).Results: After 1 month, coated implants had significantly more BIC compared with controls (CS1: 68%, p<0.0001, CS2: 63%, p=0.009, control: 52%). The rBVD was lower for all surface conditions, compared with the hostbone. After 2 months, BIC increased for all surfaces. No significant differences were measured (CS1: 71%, p=0.016, CS2: 68%, p=0.67, control: 63%). The rBVD was increased for coated implants. RFA values were 71–77 at implantation, 67–73 after 1 month and 74–75 after 2 months. Differences in rBVD and RFA were not statistically significant.Conclusions: Data analysis suggests that collagen/CS has a positive influence on bone formation after 1 month of endosseous healing.

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Journal of Clinical Periodontology

Tập 36 Số 8

698-704

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