Increased antidepressant-like effect of desipramine combined with central stimulants (caffeine and amphetamine) in mice

Central European Journal of Biology - Tập 7 - Trang 391-396 - 2012
Evelyn Robles-Molina1, Daniel Millán2, Enrique Hong3, Fengyang Huang4, Santiago Villafaña5
1Department of Pharmacology, Cinvestav, Mexico City, Mexico
2Chemistry Faculty, UAEmex, Toluca City, Mexico
3Department of Pharmacobiology, CINVESTAV, Mexico City, Mexico
4Department of Pharmacology and Toxicology, Hospital Infantil de México Federico Gomez, Mexico City, Mexico
5Superior School of Medicine, National Polytechnic Institute, Mexico City, Mexico

Tóm tắt

Desipramine is a widely used antidepressive agent that inhibits the reuptake of noradrenaline and serotonin, and central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin. This work aimed to evaluate whether the combination of these agents could produce a stronger antidepressant-like effect than either of the drugs alone. To this end, male mice were treated with different doses of desipramine, caffeine, amphetamine, desipramine-caffeine and desipramine-amphetamine. The results showed that all drugs produced decreased immobility time in the forced swimming model. The combined treatment of desipramine (0.31, 1.0 or 3.1 mg/kg i.p.) with caffeine or amphetamine (0.31 or 1 mg/kg i.p.) reduced immobility time greater than either of those drugs alone. The combined treatment of desipramine (0.31, 1 and 3.1 mg/kg i.p.) with amphetamine or caffeine (0.1 and 1 mg/kg i.p.) did not increase the motor activity significantly compared to the control. These results also suggested that drugs which promote the release of noradrenaline and serotonin could increase antidepressant-like effect of desipramine.

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Thông tin xuất bản

Central European Journal of Biology

Tập 7

391-396

Thông tin tác giả