Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

BARZEL, U.S., ESTROGENS IN THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS - A REVIEW, AMERICAN JOURNAL OF MEDICINE 85: 847 (1988).

BATAILLE, JOURNAL OF CLINICAL INVESTIGATION 88: 62 (1991).

BROXMEYER, H. E., CANCER CELLS-A MONTHLY REVIEW 3: 480 (1991).

BROXMEYER, H.E., INFLUENCE OF MURINE MAST-CELL GROWTH-FACTOR (C-KIT LIGAND) ON COLONY FORMATION BY MOUSE MARROW HEMATOPOIETIC PROGENITOR CELLS, EXPERIMENTAL HEMATOLOGY 19: 143 (1991).

ERNST, M, ESTRADIOL EFFECTS ON PROLIFERATION, MESSENGER RIBONUCLEIC-ACID FOR COLLAGEN AND INSULIN-LIKE GROWTH FACTOR-I, AND PARATHYROID HORMONE-STIMULATED ADENYLATE-CYCLASE ACTIVITY IN OSTEOBLASTIC CELLS FROM CALVARIAE AND LONG BONES, ENDOCRINOLOGY 125: 825 (1989).

GIRASOLE, G, 17-BETA-ESTRADIOL INHIBITS INTERLEUKIN-6 PRODUCTION BY BONE MARROW-DERIVED STROMAL CELLS AND OSTEOBLASTS INVITRO - A POTENTIAL MECHANISM FOR THE ANTIOSTEOPOROTIC EFFECT OF ESTROGENS, JOURNAL OF CLINICAL INVESTIGATION 89: 883 (1992).

GRAVES, L, COMPARISON OF BONE AND PARATHYROID-HORMONE AS STIMULATORS OF OSTEOCLAST DEVELOPMENT AND ACTIVITY IN CALVARIAL CELL-CULTURES FROM NORMAL AND OSTEOPETROTIC (MI/MI) MICE, JOURNAL OF CELLULAR PHYSIOLOGY 145: 102 (1990).

GRAY, T.K., ESTRADIOL STIMULATES INVITRO THE SECRETION OF INSULIN-LIKE GROWTH-FACTORS BY THE CLONAL OSTEOBLASTIC CELL-LINE, UMR106, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 158: 407 (1989).

HATTERSLEY, G, CALCITONIN RECEPTORS AS MARKERS FOR OSTEOCLASTIC DIFFERENTIATION - CORRELATION BETWEEN GENERATION OF BONE-RESORPTIVE CELLS AND CELLS THAT EXPRESS CALCITONIN RECEPTORS IN MOUSE BONE-MARROW CULTURES, ENDOCRINOLOGY 125: 1606 (1989).

HATTERSLEY, G, IDENTIFICATION OF OSTEOCLAST PRECURSORS IN MULTILINEAGE HEMATOPOIETIC COLONIES, ENDOCRINOLOGY 128: 259 (1991).

HAWLEY, T.S., LEUKOCYTOSIS IN MICE FOLLOWING LONG-TERM RECONSTITUTION WITH GENETICALLY-MODIFIED BONE-MARROW CELLS CONSTITUTIVELY EXPRESSING INTERLEUKIN-1 ALPHA OR INTERLEUKIN-6, LEUKEMIA RESEARCH 15: 659 (1991).

HEANEY, R.P., MENOPAUSAL CHANGES IN BONE REMODELING, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 92: 964 (1978).

KALU, D.N., THE OVARIECTOMIZED RAT MODEL OF POSTMENOPAUSAL BONE LOSS, BONE AND MINERAL 15: 175 (1991).

KLEIN, B, MURINE ANTI-INTERLEUKIN-6 MONOCLONAL-ANTIBODY THERAPY FOR A PATIENT WITH PLASMA-CELL LEUKEMIA, BLOOD 78: 1198 (1991).

KURIHARA, N, IDENTIFICATION OF COMMITTED MONONUCLEAR PRECURSORS FOR OSTEOCLAST-LIKE CELLS FORMED IN LONG-TERM HUMAN MARROW CULTURES, ENDOCRINOLOGY 126: 2733 (1990).

KURIHARA, N, OSTEOTROPIC FACTOR RESPONSIVENESS OF HIGHLY PURIFIED POPULATIONS OF EARLY AND LATE PRECURSORS FOR HUMAN MULTINUCLEATED CELLS EXPRESSING THE OSTEOCLAST PHENOTYPE, JOURNAL OF BONE AND MINERAL RESEARCH 6: 257 (1991).

LINDSAY, R, LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ESTROGEN - EVIDENCE FOR AN INCREASED BONE MASS AFTER DELAYED ONSET OF ESTROGEN-TREATMENT, LANCET 1: 1038 (1976).

LIU, C.C., BONE-CELL CHANGES IN ESTROGEN-INDUCED BONE-MASS INCREASE IN MICE - DISSOCIATION OF OSTEOCLASTS FROM BONE SURFACES, ANATOMICAL RECORD 229: 240 (1991).

OTSUKA, T, THE EFFECTS OF INTERLEUKIN-6 AND INTERLEUKIN-3 ON EARLY HEMATOPOIETIC EVENTS IN LONG-TERM CULTURES OF HUMAN MARROW, EXPERIMENTAL HEMATOLOGY 19: 1042 (1991).

PACIFICI, R, EFFECT OF SURGICAL MENOPAUSE AND ESTROGEN REPLACEMENT ON CYTOKINE RELEASE FROM HUMAN BLOOD MONONUCLEAR-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 5134 (1991).

POJDA, Z, INVIVO EFFECTS OF HUMAN RECOMBINANT INTERLEUKIN-6 ON HEMATOPOIETIC STEM AND PROGENITOR CELLS AND CIRCULATING BLOOD-CELLS IN NORMAL MICE, EXPERIMENTAL HEMATOLOGY 18: 1034 (1990).

ROODMAN, G.D., INTERLEUKIN-6 - A POTENTIAL AUTOCRINE PARACRINE FACTOR IN PAGETS-DISEASE OF BONE, JOURNAL OF CLINICAL INVESTIGATION 89: 46 (1992).

STARNES, H.F., ANTI-IL-6 MONOCLONAL-ANTIBODIES PROTECT AGAINST LETHAL ESCHERICHIA-COLI INFECTION AND LETHAL TUMOR-NECROSIS-FACTOR-ALPHA CHALLENGE IN MICE, JOURNAL OF IMMUNOLOGY 145: 4185 (1990).

TAKAHASHI, N, INDUCTION OF CALCITONIN RECEPTORS BY 1-ALPHA, 25-DIHYDROXYVITAMIN D3 IN OSTEOCLAST-LIKE MULTINUCLEATED CELLS FORMED FROM MOUSE BONE-MARROW CELLS, ENDOCRINOLOGY 123: 1504 (1988).

TAKAHASHI, N, OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION, ENDOCRINOLOGY 123: 2600 (1988).

TAKANOYAMAMOTO, T, DIRECT EFFECTS OF 17-BETA-ESTRADIOL ON TRABECULAR BONE IN OVARIECTOMIZED RATS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 2172 (1990).

TURNER, R.T., TAMOXIFEN INHIBITS OSTEOCLAST-MEDIATED RESORPTION OF TRABECULAR BONE IN OVARIAN HORMONE-DEFICIENT RATS, ENDOCRINOLOGY 122: 1146 (1988).

ULICH, T.R., ENDOTOXIN-INDUCED CYTOKINE GENE-EXPRESSION INVIVO .3. IL-6 MESSENGER-RNA AND SERUM-PROTEIN EXPRESSION AND THE INVIVO HEMATOLOGIC EFFECTS OF IL-6, JOURNAL OF IMMUNOLOGY 146: 2316 (1991).

Williams D. Connective Tissue Research in press.

WONG, G.G., STIMULATION OF MURINE HEMATOPOIETIC COLONY FORMATION BY HUMAN IL-6, JOURNAL OF IMMUNOLOGY 140: 3040 (1988).