Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: recommendations from The 3rd International Congress on Sudden Infant and Child Death
Tóm tắt
This report details the proceedings and conclusions from the 3rd International Congress on Unexplained Deaths in Infants and Children, held November 26–27, 2018 at the Radcliffe Institute at Harvard University. The Congress was motivated by the increasing rejection of the diagnosis Sudden Infant Death Syndrome (SIDS) in the medical examiner community, leading to falsely depressed reported SIDS rates and undermining the validity and reliability of the diagnosis, which remains a leading cause of infant and child mortality. We describe the diagnostic shift away from SIDS and the practical issues contributing to it. The Congress was attended by major figures and opinion leaders in this area from countries significantly engaged in this problem. Four categories (International Classification of Diseases (ICD)-11 categories of MH11, MH12, MH14, PB00-PB0Z) were recommended for classification, and explicit definitions and guidance were provided for death certifiers. SIDS was reframed as unexplained sudden death in infancy or SIDS/MH11 to emphasize that either term signifies the lack of explanation following a rigorous investigation. A distinct category for children over the age of 1 was recommended (MH12). Definitions and exclusions were provided for the alternative categories of accidental asphyxia and undetermined. As recommended, unexplained sudden death in infancy or SIDS on a death certificate will code a unique, trackable entity, accurately reflecting the inability to determine a definitive explanation, while satisfying surveillance needs and reliable identification for research efforts. The conclusions will be submitted to the World Health Organization for inclusion in the upcoming ICD-11.
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Tài liệu tham khảo
Shapiro-Mendoza CK, Parks SE, Brustrom J, Andrew T, Camperlengo L, Fudenberg J, et al. Variations in cause-of-death determination for sudden unexpected infant deaths. Pediatrics. 2017;140. https://doi.org/10.1542/peds.2017-0087 .
Gould SJ, Weber MA, Sebire NJ. Variation and uncertainties in the classification of sudden unexpected infant deaths among paediatric pathologists in the UK: findings of a National Delphi Study. J Clin Pathol. 2010;63:796–9.
Shapiro-Mendoza CK, Tomashek KM, Anderson RN, Wingo J. Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting. Am J Epidemiol. 2006;163:762–9.
Taylor BJ, Garstang J, Engelberts A, Obonai T, Cote A, Freemantle J, et al. International comparison of sudden unexpected death in infancy rates using a newly proposed set of cause-of-death codes. Arch Dis Child. 2015;100:1018–23.
Vege A, Rognum TO. Use of new Nordic criteria for classification of SIDS to re-evaluate diagnoses of sudden unexpected infant death in the Nordic countries. Acta Paediatr. 1997;86:391–6.
Shapiro-Mendoza CK, Camperlengo L, Ludvigsen R, Cottengim C, Anderson RN, Andrew T, et al. Classification system for the sudden unexpected infant death case registry and its application. Pediatrics. 2014;134:e210–9.
Corey T, Hanzlick R, Howard J, Nelson C, Krous H. A functional approach to sudden unexplained infant deaths. Am J Forensic Med Pathol. 2007;28:271–7.
Mitchell EA, Thompson JM, Zuccollo J, MacFarlane M, Taylor B, Elder D, et al. The combination of bed sharing and maternal smoking leads to a greatly increased risk of sudden unexpected death in infancy: the New Zealand SUDI nationwide case control study. NZ Med J. 2017;130:52–64.
Bergman AB, Beckwith JB, Ray CG. Sudden infant death syndrome: proceedings of the second international conference on causes of sudden death in infants. Seattle: University of Washington Press; 1970.
Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediat Pathol. 1991;11:677–84.
Gilbert R, Rudd P, Berry PJ, Fleming PJ, Hall E, White DG, et al. Combined effect of infection and heavy wrapping on the risk of sudden unexpected infant death. Arch Dis Child. 1992;67:171–7.
Leach CE, Blair PS, Fleming PJ, Smith IJ, Platt MW, Berry PJ, et al. Epidemiology of SIDS and explained sudden infant deaths. CESDI SUDI Research Group. Pediatrics. 1999;104:e43.
Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, Corey T, et al. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics. 2004;114:234–8.
Randall BB, Wadee SA, Sens MA, Kinney HC, Folkerth RD, Odendaal HJ, et al. A practical classification schema incorporating consideration of possible asphyxia in cases of sudden unexpected infant death. Forensic Sci Med Pathol. 2009;5:254–60.
Goldstein RD, Trachtenberg FL, Sens MA, Harty BJ, Kinney HC. Overall postneonatal mortality and rates of SIDS. Pediatrics. 2016;137. https://doi.org/10.1542/peds.2015-2298 .
Mitchell EA, Tuohy PG, Brunt JM, Thompson JM, Clements MS, Stewart AW, et al. Risk factors for sudden infant death syndrome following the prevention campaign in New Zealand: a prospective study. Pediatrics. 1997;100:835–40.
Moon RY. Task force on sudden infant deaths. SIDS and other sleep-related infant deaths: evidence base for 2016 updated recommendations for a safe infant sleeping environment. Pediatrics. 2016;138. https://doi.org/10.1542/peds.2016-2940 .
Krous HF, Haas EA, Chadwick AE, Masoumi H, Stanley C. Intrathoracic petechiae in SIDS: a retrospective population-based 15-year study. Forensic Sci Med Pathol. 2008;4:234–9.
Naeye RL. Brain-stem and adrenal abnormalities in the sudden-infant-death syndrome. Am J Clin Pathol. 1976;66:526–30.
Duncan JR, Paterson DS, Hoffman JM, Mokler DJ, Borenstein NS, Belliveau RA, et al. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA. 2010;303:430–7.
Kinney HC, Cryan JB, Haynes RL, Paterson DS, Haas EA, Mena OJ, et al. Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability. Acta Neuropathol. 2015;129:65–80.
Smith GC, Wood AM, Pell JP, White IR, Crossley JA, Dobbie R. Second-trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndrome. New Eng J Med. 2004;351:978–86.
Kinney HC, Randall LL, Sleeper LA, Willinger M, Belliveau RA, Zec N, et al. Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome. J Neuropathol Exp Neurol. 2003;62:1178–91.
Brownstein C, Goldstein RD, Thompson C, Haynes RL, Giles E, Sheidley B, et al. SCN1A variants associated with sudden infant death syndrome. Epilepsia. 2018;59:e56–62.
Mannikko R, Wong L, Tester DJ, Thor MG, Sud R, Kullmann DM, et al. Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study. Lancet. 2018;391:1483–92.
Filiano JJ, Kinney HC. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol Neonate. 1994;65:194–7.
Crandall LG, Reno L, Himes B, Robinson D. The diagnostic shift of SIDS to undetermined: are there unintended consequences? Acad Forens Path. 2017;7:212–20.
Goldstein RD, Lederman RI, Lichtenthal WG, Morris SE, Human M, Elliott AJ, et al. The grief of mothers after the sudden unexpected death of their infants. Pediatrics. 2018;141. https://doi.org/10.1542/peds.2017-3651 .
Goldstein RD, Nields HM, Kinney HC. A new approach to the investigation of sudden unexpected death. Pediatrics. 2017;140. https://doi.org/10.1542/peds.2017-0024 .
Krous HF, Chadwick AE, Crandall L, Nadeau-Manning JM. Sudden unexpected death in childhood: a report of 50 cases. Pediat Dev Pathol. 2005;8:307–19.